{"product_id":"strip2-antibody-striatin-interacting-protein-2-bha17135423","title":"STRIP2 Antibody \/ Striatin-interacting protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTRIP2 Antibody \/ Striatin-interacting protein 2 is a anti-STRIP2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STRIP2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTRIP2 antibody detects Striatin-interacting protein 2, a scaffolding protein that functions as a regulatory component of the STRIPAK complex (striatin-interacting phosphatase and kinase complex). STRIP2 integrates protein phosphatase 2A (PP2A) signaling with cytoskeletal organization, cell motility, and developmental signaling. The STRIP2 antibody is used to study PP2A-mediated signal transduction, cell morphology, and organ development.\u003cbr\u003e\u003cbr\u003eSTRIP2 is encoded by the STRIP2 gene located on human chromosome 7q34. The protein is approximately 92 kilodaltons and shares structural features with STRIP1, including coiled-coil regions that mediate interactions with striatins, kinases, and phosphatases. Through the STRIPAK complex, STRIP2 influences actin dynamics, cell polarity, and cell-cell junction formation.\u003cbr\u003e\u003cbr\u003eThe STRIP2 antibody identifies a 90-100 kilodalton protein by western blot. STRIP2 functions as a scaffold that couples kinases such as MST1\/2 and MAP4Ks to PP2A, thereby controlling phosphorylation-dependent signaling cascades. This coordination regulates tissue growth, planar cell polarity, and morphogenesis.\u003cbr\u003e\u003cbr\u003eLoss or mutation of STRIP2 disrupts cytoskeletal organization and leads to abnormal cell migration and tissue formation. In the nervous system, STRIP2 is important for axon outgrowth and synapse development. Studies have linked STRIP2 mutations to congenital myopathies and developmental disorders. In cancer, dysregulated STRIP2 expression has been observed in breast, lung, and prostate tumors, where it may promote invasive behavior.\u003cbr\u003e\u003cbr\u003eSTRIP2 serves as a crucial adaptor that integrates mechanical and chemical signaling at the cell cortex. Its interactions with the Hippo pathway components connect STRIPAK signaling to growth regulation and organ size control.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STRIP2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STRIP2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STRIP2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STRIP2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STRIP2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047292002669,"sku":"FY12520","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_0b16b252-750a-4c7e-b3f5-d19385798f7e.jpg?v=1782237015","url":"https:\/\/www.ebiohippo.com\/products\/strip2-antibody-striatin-interacting-protein-2-bha17135423","provider":"BioHippo","version":"1.0","type":"link"}