{"product_id":"strn3-antibody-striatin-3-bha17135987","title":"STRN3 Antibody \/ Striatin 3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTRN3 Antibody \/ Striatin 3 is a anti-STRN3 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STRN3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTRN3 antibody detects Striatin-3, a calmodulin-binding scaffold protein that forms part of the striatin-interacting phosphatase and kinase (STRIPAK) complex. The UniProt recommended name is Striatin-3 (STRN3). This adaptor protein coordinates protein phosphatase 2A (PP2A) signaling and regulates cytoskeletal organization, cell migration, and signal transduction.\u003cbr\u003e\u003cbr\u003eFunctionally, STRN3 antibody identifies an 837-amino-acid protein that serves as a platform for assembling PP2A catalytic and regulatory subunits along with kinases such as MST3 and GCKIII family members. STRN3 modulates dephosphorylation of signaling proteins involved in cell adhesion, polarity, and morphogenesis. Its calmodulin-binding domain enables calcium-dependent regulation of complex formation.\u003cbr\u003e\u003cbr\u003eThe STRN3 gene is located on chromosome 14q12 and is expressed in various tissues, with particularly high levels in brain and heart. STRN3 participates in diverse signaling pathways, including the Hippo pathway, where it regulates MST1\/2 kinase activity and contributes to growth control and organ size regulation. Its scaffold function allows spatial coordination between kinases and phosphatases within signaling microdomains.\u003cbr\u003e\u003cbr\u003ePathologically, aberrant STRN3 activity has been linked to cancer progression, cardiac hypertrophy, and neuronal dysfunction. Dysregulated STRIPAK signaling disrupts phosphorylation balance and cytoskeletal remodeling. STRN3 expression changes have been observed in glioblastoma and colon carcinoma, underscoring its importance in cell growth and motility.\u003cbr\u003e\u003cbr\u003eSTRN3 antibody is suitable for western blotting, immunofluorescence, and co-immunoprecipitation to identify PP2A-associated signaling complexes. \u003cbr\u003e\u003cbr\u003eStructurally, Striatin-3 includes an N-terminal caveolin-binding motif, coiled-coil regions for oligomerization, a calmodulin-binding site, and WD-repeat domains for protein interactions. This antibody aids studies into STRN3's role as a scaffold coordinating phosphatase and kinase communication across multiple pathways.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STRN3 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STRN3 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STRN3 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STRN3 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STRN3+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047311401325,"sku":"FY13085","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_1a39d090-ff85-4314-96bb-b3f43ca7fcc7.jpg?v=1782237100","url":"https:\/\/www.ebiohippo.com\/products\/strn3-antibody-striatin-3-bha17135987","provider":"BioHippo","version":"1.0","type":"link"}