{"product_id":"stxbp4-antibody-syntaxin-binding-protein-4-bha17136357","title":"STXBP4 Antibody \/ Syntaxin-binding protein 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTXBP4 Antibody \/ Syntaxin-binding protein 4 is a anti-STXBP4 Rabbit antibody Polyclonal (rabbit origin) supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P, Flow cytometry (FACS), ELISA with listed reactivity in Human. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STXBP4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTXBP4 antibody is used in research to study cellular trafficking and membrane dynamics. The encoded protein, syntaxin-binding protein 4, belongs to the Sec1\/Munc18 family, which plays an essential role in the regulation of SNARE-mediated vesicle fusion. STXBP4 interacts with syntaxins to control the docking and fusion of vesicles with target membranes, a process fundamental to intracellular transport, receptor recycling, and signal transduction. Through its role in vesicular trafficking, STXBP4 contributes to the maintenance of cellular polarity, nutrient uptake, and receptor turnover.\u003cbr\u003e\u003cbr\u003eSTXBP4 is particularly significant in processes related to glucose metabolism. It has been shown to regulate the trafficking of the glucose transporter GLUT4 to the plasma membrane in muscle and adipose tissue. This regulation is critical for insulin-stimulated glucose uptake, linking STXBP4 directly to metabolic homeostasis. Alterations in its expression or activity have been connected to insulin resistance and type 2 diabetes, making it an important subject of investigation in metabolic disease research. Beyond glucose regulation, STXBP4 participates in broader endocytic and exocytic pathways that influence receptor signaling and cellular communication.\u003cbr\u003e\u003cbr\u003eStudies suggest that STXBP4 may also contribute to cancer biology. Dysregulated expression has been observed in certain tumor types, where altered vesicle trafficking can affect growth factor signaling and proliferation. Research is ongoing to determine whether STXBP4 serves as a biomarker for cancer progression or a potential therapeutic target. Its involvement in vesicle-mediated signaling suggests that it may influence multiple pathways central to tumor growth and survival.\u003cbr\u003e\u003cbr\u003eAt the molecular level, STXBP4 is characterized by conserved domains that enable binding to syntaxins and interaction with SNARE complexes. This interaction stabilizes vesicle docking and coordinates the timing of fusion events. Experimental models demonstrate that modulation of STXBP4 can alter the efficiency of GLUT4 vesicle fusion, highlighting its central role in metabolic regulation. Antibody-based approaches are frequently used to assess protein levels, localization, and interactions within these pathways.\u003cbr\u003e\u003cbr\u003eThe STXBP4 antibody is widely applied in techniques such as western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. These applications allow scientists to investigate expression across tissues, examine subcellular distribution, and evaluate changes in disease states. When used alongside functional assays, STXBP4 detection provides valuable insight into vesicle trafficking and its consequences for metabolism and signaling. For investigators examining insulin action, metabolic disorders, or vesicular transport, the STXBP4 antibody is a reliable and versatile research tool.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STXBP4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STXBP4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STXBP4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STXBP4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STXBP4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047326736749,"sku":"RQ8939","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5a130133-9b9d-41ee-8abb-390d5896f320.jpg?v=1772019449","url":"https:\/\/www.ebiohippo.com\/products\/stxbp4-antibody-syntaxin-binding-protein-4-bha17136357","provider":"BioHippo","version":"1.0","type":"link"}