{"product_id":"stxbp6-antibody-syntaxin-binding-protein-6-bha17135519","title":"STXBP6 Antibody \/ Syntaxin-binding protein 6","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTXBP6 Antibody \/ Syntaxin-binding protein 6 is a anti-STXBP6 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STXBP6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTXBP6 antibody detects Syntaxin-binding protein 6, also known as Amisyn, a vesicle trafficking protein that regulates membrane fusion and neurotransmitter release. STXBP6 interacts with syntaxin family members and SNARE complexes, modulating vesicular exocytosis and endocytosis. The STXBP6 antibody is widely used in neurobiology and cell trafficking research to study synaptic regulation, vesicle dynamics, and membrane fusion events.\u003cbr\u003e\u003cbr\u003eSTXBP6 is encoded by the STXBP6 gene located on human chromosome 14q23.2. The protein is approximately 246 amino acids long and contains coiled-coil domains that facilitate interaction with syntaxins such as STX1A and STX3. STXBP6 localizes to the cytoplasm and plasma membrane, where it competes with other SNARE regulators to fine-tune exocytic activity.\u003cbr\u003e\u003cbr\u003eThe STXBP6 antibody detects a 28 kilodalton band by western blot and shows cytoplasmic and perinuclear puncta consistent with vesicle-associated localization. In neurons, STXBP6 modulates neurotransmitter release by inhibiting SNARE complex assembly under resting conditions and promoting controlled vesicle fusion upon stimulation. Beyond the nervous system, STXBP6 regulates exocytosis in endocrine and epithelial cells, influencing hormone and transporter release.\u003cbr\u003e\u003cbr\u003eLoss or dysregulation of STXBP6 affects vesicle cycling, leading to synaptic transmission defects and altered cellular signaling. In cancer cells, altered STXBP6 expression influences migration and invasion through effects on membrane recycling and adhesion molecule trafficking. It also plays roles in insulin granule exocytosis and endosomal trafficking in non-neuronal tissues.\u003cbr\u003e\u003cbr\u003eAs a modulator of vesicle docking and fusion, STXBP6 serves as a versatile model for understanding SNARE-mediated transport and signal propagation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STXBP6 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STXBP6 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STXBP6 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STXBP6 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STXBP6+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047294132589,"sku":"FY12616","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c9553cf6-7629-4001-82ec-6974c948dbbb.jpg?v=1782237021","url":"https:\/\/www.ebiohippo.com\/products\/stxbp6-antibody-syntaxin-binding-protein-6-bha17135519","provider":"BioHippo","version":"1.0","type":"link"}