{"product_id":"styk1-antibody-serine-threonine-tyrosine-kinase-1-bha17135745","title":"STYK1 Antibody \/ Serine\/threonine\/tyrosine kinase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSTYK1 Antibody \/ Serine\/threonine\/tyrosine kinase 1 is a anti-STYK1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e STYK1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSTYK1 antibody detects Serine\/threonine\/tyrosine kinase 1, a membrane-associated receptor-like kinase implicated in cell growth, migration, and tumor progression. Encoded by the STYK1 gene on chromosome 12q24.13, this atypical kinase belongs to the receptor protein tyrosine kinase family but exhibits dual-specificity catalytic activity, phosphorylating both serine\/threonine and tyrosine residues. STYK1 functions in intracellular signaling pathways that regulate proliferation, differentiation, and oncogenic transformation.\u003cbr\u003e\u003cbr\u003eStructurally, STYK1 is composed of a short extracellular domain, a single transmembrane helix, and a cytoplasmic kinase domain that mediates signal transduction. Although structurally similar to receptor tyrosine kinases, it lacks a classical ligand-binding domain and likely operates through intracellular signaling or interaction with other membrane proteins. STYK1 activates downstream effectors, including the MAPK\/ERK and PI3K\/AKT pathways, promoting cell survival and motility.\u003cbr\u003e\u003cbr\u003eThe STYK1 antibody is widely used in cancer biology, kinase signaling, and molecular pathology research to investigate its oncogenic potential and functional roles in signal integration. Western blot analysis detects a 48 kilodalton band corresponding to STYK1, while immunohistochemistry shows strong membrane and cytoplasmic staining in epithelial tissues and cancer cells. This antibody provides a sensitive tool for evaluating kinase expression patterns and activation states in tumor and normal tissues.\u003cbr\u003e\u003cbr\u003eOverexpression of STYK1 has been documented in lung, breast, prostate, and ovarian cancers, where it enhances tumor cell proliferation, metastasis, and resistance to apoptosis. It may function as a pseudokinase or a signaling scaffold that amplifies receptor-mediated responses. In normal physiology, STYK1 contributes to embryonic development and tissue regeneration by regulating kinase cross-talk. The STYK1 antibody enables researchers to dissect these mechanisms and explore its potential as a therapeutic target in oncology.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=STYK1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=STYK1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=STYK1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/STYK1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=STYK1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047303537005,"sku":"FY12843","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7ec07084-4e4d-429f-b242-f341872d41d4.jpg?v=1782237048","url":"https:\/\/www.ebiohippo.com\/products\/styk1-antibody-serine-threonine-tyrosine-kinase-1-bha17135745","provider":"BioHippo","version":"1.0","type":"link"}