{"product_id":"sult1c2-antibody-sulfotransferase-1c2-bha17135644","title":"SULT1C2 Antibody \/ Sulfotransferase 1C2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSULT1C2 Antibody \/ Sulfotransferase 1C2 is a anti-SULT1C2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SULT1C2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSULT1C2 antibody detects Sulfotransferase 1C2, a cytosolic enzyme that catalyzes the sulfation of hormones, xenobiotics, and small phenolic compounds, facilitating their metabolism and excretion. Encoded by the SULT1C2 gene on chromosome 2q12.3, this protein belongs to the sulfotransferase 1C family within the larger SULT superfamily of phase II metabolic enzymes. SULT1C2 uses the sulfate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to transfer sulfate groups to hydroxyl or amine substrates, increasing their solubility and promoting detoxification.\u003cbr\u003e\u003cbr\u003eSULT1C2 is expressed mainly in fetal liver, kidney, and gastrointestinal tissues, with lower levels in adult organs. It plays an important role in the developmental regulation of xenobiotic metabolism. In the liver, SULT1C2 helps conjugate thyroid hormones, estrogens, and xenobiotic phenols, contributing to endocrine balance and protection from toxic compounds. Variations in SULT1C2 expression or activity influence drug metabolism, hormone clearance, and chemical susceptibility, making it relevant to pharmacogenetics and toxicology studies.\u003cbr\u003e\u003cbr\u003eThe SULT1C2 antibody is used to study enzymatic detoxification, hormone metabolism, and tissue-specific sulfation patterns. Western blot analysis identifies a 34 kilodalton band corresponding to SULT1C2, and immunohistochemistry reveals cytoplasmic localization in hepatocytes and renal tubular cells. This antibody supports research into the biochemical pathways of sulfate conjugation and developmental regulation of phase II metabolism. Because sulfotransferases influence drug bioavailability and toxicity, the SULT1C2 antibody is a valuable reagent for pharmacological and toxicological investigations.\u003cbr\u003e\u003cbr\u003eBeyond metabolism, SULT1C2 may participate in cell signaling and differentiation by modulating the availability of bioactive molecules. Altered expression has been observed in cancers of the colon, liver, and lung, suggesting roles in tumor metabolism and chemical carcinogen processing.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SULT1C2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SULT1C2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SULT1C2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SULT1C2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SULT1C2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047298883949,"sku":"FY12741","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_efa9a8b1-70f4-4d78-8b18-965f20951b29.jpg?v=1782237033","url":"https:\/\/www.ebiohippo.com\/products\/sult1c2-antibody-sulfotransferase-1c2-bha17135644","provider":"BioHippo","version":"1.0","type":"link"}