{"product_id":"sun1-antibody-sad1-unc-84-domain-containing-protein-1-bha17135222","title":"SUN1 Antibody \/ Sad1\/UNC-84 domain-containing protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSUN1 Antibody \/ Sad1\/UNC-84 domain-containing protein 1 is a anti-SUN1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SUN1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSUN1 antibody detects Sad1\/UNC-84 domain-containing protein 1, encoded by the SUN1 gene on chromosome 7p22.3. SUN1 antibody is widely used in nuclear envelope, cytoskeletal, and cell structure research. SUN1 is an inner nuclear membrane protein that interacts with KASH domain proteins at the outer nuclear membrane to form the LINC (linker of nucleoskeleton and cytoskeleton) complex. This complex physically connects the nuclear interior with the cytoskeleton, enabling nuclear positioning, mechanotransduction, and chromosome dynamics.\u003cbr\u003e\u003cbr\u003eStructurally, SUN1 is a ~90 kDa type II transmembrane protein with a conserved SUN domain that extends into the perinuclear space. It anchors to the nuclear lamina and interacts with chromatin-associated proteins inside the nucleus. SUN1 can heterodimerize with SUN2 to form diverse LINC complexes. Expression is ubiquitous, with enrichment in proliferating and differentiating cells.\u003cbr\u003e\u003cbr\u003eFunctionally, SUN1 regulates nuclear migration, anchorage, and mechanotransduction. It is essential for meiotic chromosome pairing, telomere tethering, and centrosome-nucleus coupling. SUN1 also contributes to DNA repair and genomic stability. Researchers use SUN1 antibody to study nuclear organization, mechanobiology, and chromosome dynamics.\u003cbr\u003e\u003cbr\u003eClinically, SUN1 mutations and dysregulation are associated with laminopathies, muscular dystrophies, and neurodevelopmental disorders. Disruption of the LINC complex impairs nuclear positioning and mechanosignaling, leading to disease. SUN1 also contributes to cancer progression by altering nuclear morphology and chromatin organization. \u003cbr\u003e\u003cbr\u003eExperimentally, SUN1 antibody is used in western blotting to detect the ~90 kDa protein, in immunofluorescence microscopy to visualize nuclear envelope localization, and in immunohistochemistry to study tissue-specific expression. Co-immunoprecipitation with SUN1 antibody identifies binding partners within the LINC complex.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SUN1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SUN1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SUN1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SUN1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SUN1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047285219693,"sku":"FY12319","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4f2ade03-4034-4d0b-a3a5-ced18d7bc82a.jpg?v=1782236986","url":"https:\/\/www.ebiohippo.com\/products\/sun1-antibody-sad1-unc-84-domain-containing-protein-1-bha17135222","provider":"BioHippo","version":"1.0","type":"link"}