{"product_id":"susd2-antibody-sushi-domain-containing-protein-2-bha17136103","title":"SUSD2 Antibody \/ Sushi domain-containing protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSUSD2 Antibody \/ Sushi domain-containing protein 2 is a anti-SUSD2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SUSD2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSUSD2 antibody detects Sushi domain-containing protein 2, a type I transmembrane glycoprotein involved in cell adhesion, immune modulation, and tumor progression. The UniProt recommended name is Sushi domain-containing protein 2 (SUSD2). This protein contains multiple extracellular domains that mediate interactions with matrix components and immune receptors, influencing cell signaling and tissue organization.\u003cbr\u003e\u003cbr\u003eFunctionally, SUSD2 antibody identifies a 822-amino-acid membrane protein that includes somatomedin B, AMOP, von Willebrand factor type D, and Sushi (CCP) domains. These motifs facilitate cell-cell and cell-matrix adhesion while modulating immune recognition and tumor microenvironment interactions. SUSD2 supports epithelial integrity and participates in TGF-beta and Wnt signaling pathways that control cell differentiation and invasion.\u003cbr\u003e\u003cbr\u003eThe SUSD2 gene is located on chromosome 22q11.23 and is expressed in endothelial cells, epithelial tissues, and several cancer types. Its expression is elevated in breast, ovarian, and colorectal cancers, where it contributes to tumor growth, angiogenesis, and immune evasion. In normal physiology, SUSD2 is thought to support epithelial repair and maintain mucosal homeostasis.\u003cbr\u003e\u003cbr\u003ePathologically, overexpression of SUSD2 promotes tumor cell adhesion, migration, and immune suppression through interactions with Galectin-1 and other immunoregulatory factors. Conversely, in certain contexts, SUSD2 may enhance antitumor immune responses by facilitating macrophage activation. Research using SUSD2 antibody supports studies in cancer immunology, cell adhesion, and signal transduction.\u003cbr\u003e\u003cbr\u003eSUSD2 antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect adhesion-related glycoproteins. \u003cbr\u003e\u003cbr\u003eStructurally, Sushi domain-containing protein 2 features multiple modular domains connected by disulfide bonds, forming a flexible extracellular scaffold that mediates protein-protein interactions. The cytoplasmic tail contains potential phosphorylation sites that regulate receptor signaling and intracellular trafficking. This antibody enables investigation of SUSD2's functional role in adhesion, cancer progression, and immune modulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SUSD2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SUSD2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SUSD2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SUSD2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SUSD2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047319626093,"sku":"FY13201","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7ef63d24-bc2e-495d-badd-3ee505eb1ce9.jpg?v=1782237086","url":"https:\/\/www.ebiohippo.com\/products\/susd2-antibody-sushi-domain-containing-protein-2-bha17136103","provider":"BioHippo","version":"1.0","type":"link"}