{"product_id":"swt1-antibody-c1orf26-bha17135301","title":"SWT1 Antibody \/ C1orf26","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSWT1 Antibody \/ C1orf26 is a anti-SWT1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SWT1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe SWT1 antibody targets Pre-mRNA-splicing factor SWT1 homolog, a nuclear protein encoded by the SWT1 gene. This enzyme is involved in RNA processing, quality control, and surveillance pathways that ensure proper pre-mRNA splicing and ribonucleoprotein maturation. Pre-mRNA-splicing factor SWT1 homolog is an RNA endonuclease that trims aberrant or misprocessed RNA precursors, maintaining transcriptome fidelity. The SWT1 antibody provides researchers with a reliable tool for studying nuclear RNA metabolism, splicing complex dynamics, and gene expression regulation.\u003cbr\u003e\u003cbr\u003ePre-mRNA-splicing factor SWT1 homolog localizes to nucleoplasmic and nucleolar regions where active splicing occurs. It contains conserved zinc-finger and endonuclease domains required for RNA substrate recognition and cleavage. The SWT1 antibody allows visualization of this nuclear factor, enabling the investigation of its roles in processing small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs). Through these actions, SWT1 contributes to ribosome biogenesis and overall RNA quality assurance within the nucleus.\u003cbr\u003e\u003cbr\u003eLoss or dysfunction of Pre-mRNA-splicing factor SWT1 homolog leads to accumulation of defective pre-mRNA and abnormal spliceosome assembly, disrupting normal gene expression. The SWT1 antibody aids in identifying changes in SWT1 expression or localization in experimental systems subjected to transcriptional stress or RNA splicing inhibition. Studies indicate that this factor participates in safeguarding the transcriptome against RNA processing defects that can trigger cellular stress responses.\u003cbr\u003e\u003cbr\u003eBeyond RNA metabolism, SWT1 may interact with other nuclear RNA decay enzymes, coordinating pathways that remove splicing intermediates and cryptic transcripts. The SWT1 antibody supports mechanistic studies exploring these complexes, helping define how nuclear RNA degradation interfaces with splicing surveillance. Its conservation from yeast to humans highlights an evolutionarily stable role in RNA integrity maintenance.\u003cbr\u003e\u003cbr\u003eThe SWT1 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, showing strong nuclear staining consistent with RNA processing activity.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SWT1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SWT1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SWT1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SWT1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SWT1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047287218541,"sku":"FY12398","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_065a99ae-41e6-42e2-8f31-d4cd380d6e54.jpg?v=1782236998","url":"https:\/\/www.ebiohippo.com\/products\/swt1-antibody-c1orf26-bha17135301","provider":"BioHippo","version":"1.0","type":"link"}