{"product_id":"syncytin-1-antibody-ervw-1-bha17128143","title":"Syncytin 1 Antibody \/ ERVW-1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eSyncytin 1 Antibody \/ ERVW-1 is an antibody targeting \u003cstrong\u003eERVW-1\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ERVW-1.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, IHC-P (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eSyncytin 1 is a protein encoded by the ERVW-1 gene, which belongs to the human endogenous retrovirus W family. Endogenous retroviruses are remnants of ancient viral infections that have inserted their genetic material into the human genome. These genetic elements have been preserved through generations and have been co-opted by our bodies for various functions. One of the most intriguing functions of Syncytin 1 is its role in placental development. During pregnancy, Syncytin 1 is expressed in the trophoblast cells of the placenta, where it helps in the formation of syncytia - multinucleated cells that facilitate nutrient exchange between the mother and the growing fetus. This process is essential for the successful progression of pregnancy and the health of both the mother and the baby. Recent research has pointed to its involvement in various physiological processes, including immune modulation and tissue repair. Its expression has been detected in the brain, where it may play a role in neuroprotection and synaptic plasticity.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eImmunohistochemistry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q9UQF0 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q9UQF0 - Gene search: ERVW-1 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ERVW-1 - Ensembl search: ERVW-1 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ERVW-1 - PubMed search: ERVW-1 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ERVW-1+antibody - Reactome search: ERVW-1 — Reactome — https:\/\/reactome.org\/content\/query?q=ERVW-1 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.05 ml","offer_id":53046408773997,"sku":"F55080-0.05ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.2 ml","offer_id":53046470836589,"sku":"F55080-0.2ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_8b319608-b7cb-4c6d-9d41-394e7cedc109.jpg?v=1772000496","url":"https:\/\/www.ebiohippo.com\/products\/syncytin-1-antibody-ervw-1-bha17128143","provider":"BioHippo","version":"1.0","type":"link"}