{"product_id":"syngr1-antibody-synaptogyrin-1-bha17135591","title":"SYNGR1 Antibody \/ Synaptogyrin 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSYNGR1 Antibody \/ Synaptogyrin 1 is a anti-SYNGR1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SYNGR1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSYNGR1 antibody targets Synaptogyrin 1, an integral membrane protein of synaptic vesicles that modulates neurotransmitter release and vesicle recycling. Encoded by the SYNGR1 gene on chromosome 22q13.1, Synaptogyrin 1 belongs to the synaptogyrin family of small transmembrane proteins highly conserved among vertebrates. It contains four transmembrane domains with both N- and C-termini facing the cytoplasm and interacts with synaptophysin and vesicular transport machinery. Synaptogyrin 1 contributes to the organization of presynaptic vesicle pools and may influence the kinetics of neurotransmitter exocytosis.\u003cbr\u003e\u003cbr\u003eSynaptogyrin 1 is abundantly expressed in neurons throughout the central and peripheral nervous systems, particularly within the hippocampus, cortex, and cerebellum. It colocalizes with synaptophysin at presynaptic terminals and has been implicated in modulating short-term synaptic plasticity. Genetic studies suggest that SYNGR1 plays a role in neuropsychiatric conditions including schizophrenia and bipolar disorder, where altered expression affects synaptic connectivity. By maintaining the balance between vesicle docking and endocytosis, Synaptogyrin 1 ensures efficient neurotransmission under repetitive stimulation.\u003cbr\u003e\u003cbr\u003eThe SYNGR1 antibody is widely used in neuroscience research to identify synaptic vesicles and study presynaptic organization. Immunohistochemical staining with this antibody shows punctate labeling along axons and synaptic terminals, corresponding to vesicle-rich regions. In western blot analysis, Synaptogyrin 1 appears as a 25 kilodalton band. Its high conservation allows cross-reactivity among mammalian species, making the antibody suitable for studies in human, mouse, and rat tissues. By labeling presynaptic vesicles, the SYNGR1 antibody facilitates mapping of synaptic networks and quantitative analysis of synapse density across brain regions.\u003cbr\u003e\u003cbr\u003eBeyond basic neuroscience, Synaptogyrin 1 has clinical relevance. Expression profiling in neurodegenerative diseases such as Alzheimer's and Parkinson's reveals synaptic protein loss correlating with disease progression. Reduced SYNGR1 expression has also been linked to cognitive decline and altered synaptic activity in psychiatric disorders. Functionally, Synaptogyrin 1 may influence neurotransmitter transporter trafficking, including those for serotonin and dopamine. The antibody thus supports a broad range of studies spanning molecular synaptic physiology, disease biomarker discovery, and neural circuit mapping.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SYNGR1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SYNGR1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SYNGR1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SYNGR1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SYNGR1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047296098669,"sku":"FY12688","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_25344b1e-91f3-496a-8be8-3bb2e091453c.jpg?v=1782237029","url":"https:\/\/www.ebiohippo.com\/products\/syngr1-antibody-synaptogyrin-1-bha17135591","provider":"BioHippo","version":"1.0","type":"link"}