{"product_id":"sypl1-antibody-synaptophysin-like-protein-1-bha17135401","title":"SYPL1 Antibody \/ Synaptophysin like protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSYPL1 Antibody \/ Synaptophysin like protein 1 is a anti-SYPL1 Rabbit antibody Recombinant Rabbit Monoclonal clone 32S17 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SYPL1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32S17, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSYPL1 antibody detects synaptophysin like protein 1, a membrane protein encoded by the SYPL1 gene. SYPL1 is a small integral membrane protein localized to vesicular structures and associated with synaptic vesicle trafficking. While structurally related to synaptophysin, SYPL1 has distinct expression patterns and functions. It is found in endocrine tissues, immune cells, and certain epithelial cells, suggesting broader roles beyond the nervous system.\u003cbr\u003e\u003cbr\u003eSYPL1 antibody is widely applied in research on vesicle biology, secretion, and cancer. SYPL1 has been implicated in regulated exocytosis, immune granule release, and membrane trafficking. In pancreatic islets, SYPL1 supports hormone release, while in immune cells it contributes to vesicular storage and secretion of signaling molecules. Detecting SYPL1 allows researchers to explore how vesicle associated proteins coordinate secretory pathways in different tissues.\u003cbr\u003e\u003cbr\u003eThe antibody is validated for western blotting, immunohistochemistry, and immunofluorescence. In western blot assays, SYPL1 antibody detects protein bands of the expected size, enabling assessment of expression across samples. Immunohistochemistry reveals SYPL1 expression in pancreas, spleen, and epithelial tissues. Immunofluorescence demonstrates punctate localization in vesicular structures consistent with roles in trafficking and secretion.\u003cbr\u003e\u003cbr\u003eSYPL1 has also been studied in cancer biology. Elevated expression has been reported in hepatocellular carcinoma and other malignancies, where it correlates with proliferation, survival, and therapy resistance. By applying SYPL1 antibody, scientists can investigate how vesicle associated proteins contribute to oncogenesis and evaluate their potential as biomarkers or therapeutic targets.\u003cbr\u003e\u003cbr\u003eSYPL1 also plays roles in development and immune regulation. In hematopoietic cells, it contributes to granule release and immune defense. In development, SYPL1 influences vesicle formation and trafficking, ensuring proper signaling during differentiation. This versatility highlights the importance of SYPL1 antibody in both basic biology and translational research.\u003cbr\u003e\u003cbr\u003eSYPL1 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SYPL1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SYPL1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SYPL1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SYPL1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SYPL1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047290200429,"sku":"FY12498","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9c9ff3b1-0bcd-4055-828e-903be63dda4f.jpg?v=1772019301","url":"https:\/\/www.ebiohippo.com\/products\/sypl1-antibody-synaptophysin-like-protein-1-bha17135401","provider":"BioHippo","version":"1.0","type":"link"}