{"product_id":"syt17-antibody-synaptotagmin-17-bha17135624","title":"SYT17 Antibody \/ Synaptotagmin 17","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSYT17 Antibody \/ Synaptotagmin 17 is a anti-SYT17 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Human. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SYT17\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSYT17 antibody detects Synaptotagmin-17 (also known as Synaptotagmin XVII), a member of the synaptotagmin family of membrane-trafficking proteins that regulate vesicle docking and fusion. Encoded by the SYT17 gene on chromosome 16q21, this isoform differs from classical synaptotagmins by lacking the N-terminal transmembrane region, suggesting a soluble or peripheral membrane association. SYT17 contains tandem C2 domains that mediate calcium-dependent phospholipid binding and interactions with SNARE complex proteins. Through these domains, Synaptotagmin-17 contributes to intracellular trafficking, membrane remodeling, and possibly exocytosis in non-neuronal tissues.\u003cbr\u003e\u003cbr\u003eUnlike canonical synaptotagmins that function in neurotransmitter release, SYT17 is primarily expressed in non-synaptic regions of the brain, kidney, and liver, where it regulates membrane trafficking between the endoplasmic reticulum and Golgi apparatus. It may modulate calcium-sensitive steps in vesicle fusion and contribute to secretory pathway organization. In neurons, SYT17 expression has been linked to dendritic cargo transport and neurite extension, implicating it in intracellular trafficking rather than synaptic vesicle exocytosis. Loss or mutation of SYT17 alters intracellular transport dynamics, potentially affecting neural development and metabolic processes.\u003cbr\u003e\u003cbr\u003eThe SYT17 antibody is used in neuroscience and cell biology to detect Synaptotagmin-17 expression and subcellular localization. Western blot analysis typically identifies a ~50 kilodalton band, while immunofluorescence reveals punctate cytoplasmic staining consistent with endomembrane localization. In neuronal cultures, SYT17 co-localizes with markers of the Golgi network and early endosomes, indicating its role in vesicular transport. The antibody aids in studying membrane trafficking, calcium signaling, and synaptotagmin family diversification.\u003cbr\u003e\u003cbr\u003eFunctionally, SYT17 binds phospholipids in a calcium-dependent manner and may participate in regulating the SNARE machinery under specific conditions. It also interacts with proteins involved in vesicle tethering and sorting. Dysregulated SYT17 expression has been reported in certain neurodegenerative disorders and cancers, though its exact pathogenic roles remain under investigation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SYT17 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SYT17 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SYT17 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SYT17 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SYT17+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047298261357,"sku":"FY12721","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_699bbcc2-2155-43c5-8947-0b0f79856cc7.jpg?v=1782237039","url":"https:\/\/www.ebiohippo.com\/products\/syt17-antibody-synaptotagmin-17-bha17135624","provider":"BioHippo","version":"1.0","type":"link"}