{"product_id":"syvn1-antibody-synoviolin-hrd1-bha17136046","title":"SYVN1 Antibody \/ Synoviolin \/ HRD1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eSYVN1 Antibody \/ Synoviolin \/ HRD1 is a anti-SYVN1 Rabbit antibody Recombinant Rabbit Monoclonal clone 32S38 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow cytometry (FACS) with listed reactivity in Human, Mouse, Rat. Reported localization: ER.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e SYVN1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32S38, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, IP, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eSYVN1 antibody detects Synoviolin, also called HRD1, encoded by the SYVN1 gene. Synoviolin is an endoplasmic reticulum (ER) resident E3 ubiquitin ligase that plays a central role in ER-associated degradation (ERAD), the process that disposes of misfolded proteins from the ER. By tagging substrates with ubiquitin, Synoviolin directs them for proteasomal degradation, thereby maintaining protein homeostasis in the secretory pathway. SYVN1 antibody provides researchers with a critical reagent to study protein quality control, ER stress, and disease.\u003cbr\u003e\u003cbr\u003eER-associated degradation is essential for secretory pathway fidelity. Research using SYVN1 antibody has shown that Synoviolin forms part of the ER membrane-anchored ubiquitin ligase complex, recognizing unfolded substrates and ubiquitinating them for retrotranslocation and proteasomal degradation. This prevents accumulation of misfolded proteins, protecting cells from ER stress and apoptosis. By maintaining proteostasis, SYVN1 safeguards secretory and metabolic tissues.\u003cbr\u003e\u003cbr\u003eAberrant expression of Synoviolin has been linked to cancer, fibrosis, and autoimmune disease. Studies with SYVN1 antibody have revealed that overexpression promotes tumor survival by reducing ER stress-induced apoptosis. In rheumatoid arthritis, Synoviolin overexpression in synovial tissue contributes to pathological proliferation and joint destruction. These findings highlight SYVN1 as both a biomarker and a potential therapeutic target.\u003cbr\u003e\u003cbr\u003eBeyond pathology, SYVN1 contributes to normal development and physiology. Research using SYVN1 antibody has shown that knockout mice exhibit embryonic lethality due to defective ERAD, confirming its essential function. In the liver, SYVN1 regulates lipid metabolism and detoxification processes by controlling ER protein load. These functions underscore the importance of Synoviolin in both health and disease.\u003cbr\u003e\u003cbr\u003eSYVN1 antibody is widely used in western blotting, immunohistochemistry, and immunoprecipitation. Western blotting confirms expression in liver and synovium, immunohistochemistry highlights tissue-specific overexpression in disease, and immunoprecipitation identifies substrates ubiquitinated by Synoviolin. These methods make SYVN1 antibody a versatile tool in cell biology and translational research.\u003cbr\u003e\u003cbr\u003eBy supplying validated SYVN1 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=SYVN1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=SYVN1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=SYVN1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/SYVN1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=SYVN1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047313760621,"sku":"FY13144","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d39deea2-522d-4543-b715-1cfeed064494.jpg?v=1772019406","url":"https:\/\/www.ebiohippo.com\/products\/syvn1-antibody-synoviolin-hrd1-bha17136046","provider":"BioHippo","version":"1.0","type":"link"}