{"product_id":"tagap-antibody-t-cell-activation-rho-gtpase-activating-protein-bha17136124","title":"TAGAP Antibody \/ T cell activation Rho GTPase activating protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTAGAP Antibody \/ T cell activation Rho GTPase activating protein is a anti-TAGAP Rabbit antibody Recombinant Rabbit Monoclonal clone 30T40 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunoprecipitation (IP) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TAGAP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30T40, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTAGAP antibody detects T cell activation Rho GTPase activating protein, encoded by the TAGAP gene. T cell activation Rho GTPase activating protein is a cytoplasmic regulator of the Rho family of small GTPases, controlling actin cytoskeleton remodeling and T cell receptor signaling. TAGAP antibody provides researchers with a reliable reagent to study immune cell activation, autoimmunity, and cytoskeletal regulation.\u003cbr\u003e\u003cbr\u003eT cell activation Rho GTPase activating protein functions as a negative regulator of Rho GTPases by stimulating their intrinsic GTPase activity, converting active GTP bound forms into inactive GDP bound forms. Research using TAGAP antibody has shown that this regulation influences T cell activation thresholds and cytoskeletal reorganization during immune responses. By fine tuning Rho signaling, TAGAP modulates T cell migration, adhesion, and synapse formation, processes that are critical for adaptive immunity.\u003cbr\u003e\u003cbr\u003eGenome wide association studies have identified TAGAP as a susceptibility locus for several autoimmune diseases, including multiple sclerosis, type 1 diabetes, rheumatoid arthritis, and celiac disease. Studies with TAGAP antibody have revealed that altered expression or polymorphisms in TAGAP influence T cell function, predisposing individuals to dysregulated immune responses. These findings highlight TAGAP as a genetic link between cytoskeletal regulation and autoimmunity.\u003cbr\u003e\u003cbr\u003eBeyond its role in T cells, TAGAP is expressed in other immune lineages such as dendritic cells and macrophages. Research using TAGAP antibody has demonstrated roles in innate immune signaling, where TAGAP contributes to pattern recognition receptor pathways and cytokine production. This expands its relevance beyond adaptive immunity to innate immune regulation.\u003cbr\u003e\u003cbr\u003eTAGAP antibody is widely used in western blotting, immunohistochemistry, and flow cytometry. Western blotting demonstrates inducible expression after immune stimulation, immunohistochemistry shows localization in lymphoid tissues, and flow cytometry quantifies expression across immune subsets. These applications make TAGAP antibody a versatile tool in immunology research.\u003cbr\u003e\u003cbr\u003eBy supplying validated TAGAP antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TAGAP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TAGAP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TAGAP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TAGAP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TAGAP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047319134573,"sku":"FY13222","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_3fea1ce7-12f3-4a18-bc2f-7d6ff174275f.jpg?v=1782237074","url":"https:\/\/www.ebiohippo.com\/products\/tagap-antibody-t-cell-activation-rho-gtpase-activating-protein-bha17136124","provider":"BioHippo","version":"1.0","type":"link"}