{"product_id":"tanshinone-ii-a-sodium-sulfonate-bhb21300342","title":"Tanshinone II-A sodium sulfonate","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sulfonate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e DS-201\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 69659-80-9\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C19H17O6SNa.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 10-200 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e 10 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e 10 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e KCa1.1 channel\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Tanshinone II-A sodium sulfonate is a KCa1.1 channel opener1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e DS-201\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eKCa1.1 channel is a large conductance Calcium-activated potassium channel (BKCa) known to regulate the repolarization of action potential discharge through molecular association with high voltage activated calcium channels.Tanshinone II-A sodium sulfonate (TIIAS) is a water soluble derivative of Tanshinone IIA. Tanshinone IIA is an active constituent of the herb Danshen (Salvia miltiorrhiza) widely used in Chinese traditional medicine for coronary artery disease, hypertension and other cardiovascular diseases due to its properties of arterial dilatation. TIIAS is a synthetic opener of KCa1.1 channels with an effective concentration 10-200 μM. TIIAS increases the total permeability of BKCa in a concentration dependent manner. TIIAS has an EC50 of 111.5 μM at 0.01 μM Ca2+ and an EC50 of 68.5 μM at 0.1 μM Ca2+ 2. Similar to Danshen, TIIAS has beneficial effects on cardiac vasodilatation, reduction of oxidative stress and lipid profile. Interestingly, when used in a rat model of preeclampsia TIIAS reduced oxidative stress, however it did not lead to an improvement in pregnancy outcome criteria such as maternal blood pressure and fetal biometrics3. TIIAS was also found to have analgesic properties in neuropathic pain via inhibition of the spinal astrocytic JNK\/MCP-1 pathway and the reduction of IL-1β and TNF-α expression4.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249714520429,"sku":"T-165-10MG-1","price":134.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311578145133,"sku":"T-165-25MG-1","price":297.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311578177901,"sku":"T-165-5MG-1","price":85.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311578210669,"sku":"T-165-50MG-1","price":476.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/T-165_gr.gif?v=1778544455","url":"https:\/\/www.ebiohippo.com\/products\/tanshinone-ii-a-sodium-sulfonate-bhb21300342","provider":"BioHippo","version":"1.0","type":"link"}