{"product_id":"taok1-antibody-tao-kinase-1-bha17135852","title":"TAOK1 Antibody \/ TAO kinase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTAOK1 Antibody \/ TAO kinase 1 is a anti-TAOK1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunoprecipitation (IP), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TAOK1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IP, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTAOK1 antibody detects TAO kinase 1, a serine\/threonine-protein kinase involved in stress signaling, cytoskeletal dynamics, and neuronal development. The UniProt recommended name is Serine\/threonine-protein kinase TAO1 (TAOK1), also known as MAP3K16 or thousand and one amino acid kinase 1. This kinase functions upstream of mitogen-activated protein kinase (MAPK) cascades, including the p38 and JNK pathways, which regulate apoptosis, microtubule stability, and cellular stress responses.\u003cbr\u003e\u003cbr\u003eFunctionally, TAOK1 antibody identifies a 100 kDa enzyme that phosphorylates and activates MAP2Ks such as MKK3 and MKK6, leading to downstream activation of p38 MAPK. TAOK1 also modulates the cytoskeleton by interacting with microtubule-associated proteins, including MARK kinases. This regulation is critical for neuronal polarity, axon specification, and dendrite formation. During mitosis, TAOK1 contributes to spindle orientation and chromosome alignment, linking stress signaling with cell-cycle progression.\u003cbr\u003e\u003cbr\u003eThe TAOK1 gene is located on chromosome 17q11.2 and encodes a multi-domain kinase composed of an N-terminal catalytic domain and a C-terminal regulatory region. It functions as both a signaling hub and structural organizer by localizing to centrosomes, Golgi membranes, and the cytoplasmic microtubule network. Autophosphorylation and stress-induced activation enhance TAOK1 activity, enabling rapid response to environmental and mechanical stimuli.\u003cbr\u003e\u003cbr\u003eTAOK1 has gained prominence for its role in neurodevelopment. Mutations or dysregulation of TAOK1 are associated with neurodevelopmental disorders, including autism spectrum disorder and intellectual disability. Experimental evidence shows that TAOK1 depletion impairs axonal growth, disrupts neuronal morphology, and alters synaptic signaling. In non-neuronal cells, TAOK1 mediates apoptotic signaling through activation of p38 and JNK under oxidative or osmotic stress conditions.\u003cbr\u003e\u003cbr\u003eTAOK1 antibody is a versatile reagent for analyzing kinase signaling, cytoskeletal organization, and stress-induced apoptosis. It is commonly used in immunoblotting, immunofluorescence, and kinase activity assays to evaluate TAOK1 expression and activation. In cancer research, TAOK1 contributes to epithelial-to-mesenchymal transition (EMT) and metastasis, while in neurons, it supports differentiation and network connectivity.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TAOK1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TAOK1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TAOK1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TAOK1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TAOK1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047307469165,"sku":"FY12950","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_1fd40ae8-0da4-4ce6-a9ef-00ab07f090fb.jpg?v=1782237070","url":"https:\/\/www.ebiohippo.com\/products\/taok1-antibody-tao-kinase-1-bha17135852","provider":"BioHippo","version":"1.0","type":"link"}