{"product_id":"taok1-antibody-thousand-and-one-amino-acid-protein-kinase-1-bha17135354","title":"TAOK1 Antibody \/ Thousand and one amino acid protein kinase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTAOK1 Antibody \/ Thousand and one amino acid protein kinase 1 is a anti-TAOK1 Rabbit antibody Recombinant Rabbit Monoclonal clone 30T29 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TAOK1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30T29, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTAOK1 antibody detects thousand and one amino acid protein kinase 1, a serine threonine kinase encoded by the TAOK1 gene. TAOK1 belongs to the MAP kinase kinase kinase family and regulates diverse cellular processes including cytoskeletal organization, stress signaling, and apoptosis. Through phosphorylation of downstream MAP kinases, TAOK1 influences cell cycle progression and response to environmental stress.\u003cbr\u003e\u003cbr\u003eTAOK1 antibody is widely used in studies of kinase signaling, neuronal development, and cancer biology. In neurons, TAOK1 has been linked to axon outgrowth, dendritic branching, and synaptic plasticity. Mutations and altered expression of TAOK1 have been implicated in neurodevelopmental disorders including autism spectrum disorder. By detecting TAOK1, researchers can evaluate how changes in kinase signaling contribute to brain development and function.\u003cbr\u003e\u003cbr\u003eThe antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence. Western blot assays detect bands corresponding to TAOK1 isoforms across different tissues. Immunohistochemistry highlights expression in developing brain regions, while immunofluorescence provides subcellular localization at cytoskeletal structures and kinases in signaling complexes.\u003cbr\u003e\u003cbr\u003eTAOK1 also regulates apoptotic pathways through activation of stress activated protein kinases. It contributes to programmed cell death under stress conditions, linking it to cancer and degenerative disease. Elevated TAOK1 expression has been reported in tumors, where it may affect proliferation and survival pathways. By applying TAOK1 antibody, scientists can study its role in balancing survival and death signals in health and disease.\u003cbr\u003e\u003cbr\u003eTAOK1 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TAOK1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TAOK1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TAOK1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TAOK1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TAOK1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047289905517,"sku":"FY12451","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_256718aa-6b54-4a1d-a7be-1806cbf2519f.jpg?v=1772019281","url":"https:\/\/www.ebiohippo.com\/products\/taok1-antibody-thousand-and-one-amino-acid-protein-kinase-1-bha17135354","provider":"BioHippo","version":"1.0","type":"link"}