{"product_id":"taok2-antibody-tao-kinase-2-bha17136190","title":"TAOK2 Antibody \/ TAO kinase 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTAOK2 Antibody \/ TAO kinase 2 is a anti-TAOK2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TAOK2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTAOK2 antibody recognizes TAO kinase 2, a serine\/threonine-protein kinase encoded by the TAOK2 gene, which functions as an upstream activator in multiple MAPK signaling cascades. TAOK2 (Thousand And One Kinase 2) belongs to the STE20 kinase family and regulates cytoskeletal dynamics, stress response pathways, and neuronal development. The kinase localizes to both the cytoplasm and centrosomes, where it phosphorylates downstream kinases such as MAP2K3 and MAP2K6 to activate p38 MAPK signaling. Through these pathways, TAOK2 influences apoptosis, differentiation, and responses to cellular stress.\u003cbr\u003e\u003cbr\u003eTAOK2 plays a critical role in neuronal morphology and synaptic function. It regulates microtubule stability and axon elongation through phosphorylation of cytoskeletal proteins, including microtubule-associated proteins. In developing neurons, TAOK2 helps establish dendritic spine structure and connectivity, contributing to proper neural circuit formation. Mutations and deletions of TAOK2 have been linked to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia, underscoring its importance in brain development. Studies show that TAOK2 interacts with autism risk proteins including SHANK1 and DISC1 and modulates signaling through Rho GTPases and JNK kinases.\u003cbr\u003e\u003cbr\u003eThe TAOK2 gene is located on chromosome 16p11.2, a genomic region frequently associated with copy number variations implicated in neurodevelopmental conditions. TAOK2 exists in several alternatively spliced isoforms with distinct subcellular localization and regulatory functions. The full-length protein contains an N-terminal kinase domain and a C-terminal coiled-coil domain that mediates protein-protein interactions. TAOK2 activation can be induced by oxidative stress, UV radiation, or cytokine stimulation, linking it to broader cellular stress responses and apoptosis regulation.\u003cbr\u003e\u003cbr\u003eImmunohistochemical staining using TAOK2 antibody shows expression in brain tissue, particularly in the cortex and hippocampus, as well as in heart and testis. It has been used to study MAPK pathway signaling, neuronal cytoskeleton remodeling, and stress-induced apoptosis. TAOK2 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TAOK2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TAOK2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TAOK2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TAOK2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TAOK2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047321690477,"sku":"FY13288","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_95034e58-69cb-4949-a0c7-559f77a87db2.jpg?v=1782237103","url":"https:\/\/www.ebiohippo.com\/products\/taok2-antibody-tao-kinase-2-bha17136190","provider":"BioHippo","version":"1.0","type":"link"}