{"product_id":"tar-dna-binding-protein-43-antibody-tdp43-tardbp-bha17136303","title":"TAR DNA binding protein 43 Antibody \/ TDP43 \/ TARDBP","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTAR DNA binding protein 43 Antibody \/ TDP43 \/ TARDBP is a anti-43 Rabbit antibody Recombinant Rabbit Monoclonal clone 26T75 supplied in Purified format. Recommended for workflows such as Western blot (WB), Immunofluorescence (IF), IHC-P with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e 43\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 26T75, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IF, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTAR DNA binding protein 43 is a DNA\/RNA-binding protein that shuttles between nucleus and cytoplasm to coordinate RNA metabolism. It recognizes UG-rich sequences via 2 RNA recognition motifs and uses a glycine-rich C-terminus to assemble ribonucleoprotein complexes. TAR DNA binding protein 43 regulates alternative splicing, transcript stability, 3' end processing, and mRNA transport, integrating these steps with transcription-coupled RNA handling across diverse cell types.\u003cp\u003eIt participates in stress-responsive RNA granule dynamics and controlled phase behavior, linking RNA sorting to protein quality control pathways. Its nuclear enrichment, regulated export, and post-translational modification states offer quantitative readouts for studies of RNA processing, trafficking, and cellular adaptation in defined model systems.\u003c\/p\u003e\n\u003cp\u003eThe \u003cb\u003eTAR DNA binding protein 43 antibody\u003c\/b\u003e from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=43 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=43 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=43 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/43 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=43+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047324541293,"sku":"RQ8884","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_dd98a789-b165-437d-9ead-04a304e8d7e5.jpg?v=1772019442","url":"https:\/\/www.ebiohippo.com\/products\/tar-dna-binding-protein-43-antibody-tdp43-tardbp-bha17136303","provider":"BioHippo","version":"1.0","type":"link"}