{"product_id":"tardbp-antibody-tar-dna-binding-protein-43-tdp43-bha17136302","title":"TARDBP Antibody \/ TAR DNA binding protein 43 \/ TDP43","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTARDBP Antibody \/ TAR DNA binding protein 43 \/ TDP43 is a anti-TARDBP Rabbit antibody Recombinant Rabbit Monoclonal clone ABAB-20 supplied in Purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TARDBP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone ABAB-20, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTARDBP encodes TDP-43, a DNA\/RNA-binding protein that regulates pre-mRNA splicing, transcript stability, and RNA transport. It shuttles between nucleus and cytoplasm and recognizes UG-rich elements through 2 RNA recognition motifs (RRM1\/RRM2), while a low-complexity, glycine-rich C-terminus supports protein–protein and ribonucleoprotein assembly. Through these activities, TDP-43 coordinates RNA processing programs that influence neuronal function and broader cell biology.\u003cp\u003eTDP-43 participates in stress-responsive ribonucleoprotein remodeling and interacts with components of transcription, splicing, and translation pathways. Changes in localization, solubility, or post-translational status are widely monitored as readouts in studies of RNA metabolism, proteostasis, and cellular stress adaptation across model systems.\u003c\/p\u003e\n\u003cp\u003eThe \u003cb\u003eTARDBP antibody\u003c\/b\u003e enables specific detection of endogenous TDP-43 in applications such as western blot, immunofluorescence, immunohistochemistry, and immunoprecipitation. Researchers use the TARDBP antibody from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TARDBP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TARDBP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TARDBP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TARDBP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TARDBP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047325622637,"sku":"RQ8883","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2a32ea2d-4b6b-4dcc-9090-0cf7467c6248.jpg?v=1772019440","url":"https:\/\/www.ebiohippo.com\/products\/tardbp-antibody-tar-dna-binding-protein-43-tdp43-bha17136302","provider":"BioHippo","version":"1.0","type":"link"}