{"product_id":"tas2r10-antibody-taste-receptor-type-2-member-10-bha17136264","title":"TAS2R10 Antibody \/ Taste receptor type 2 member 10","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTAS2R10 Antibody \/ Taste receptor type 2 member 10 is a anti-TAS2R10 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Flow cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Western blot (WB) with listed reactivity in Human, Mouse, Rat. Reported localization: Vesicles, Actin filaments, Plasma membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TAS2R10\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, FACS, IF, IHC, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTAS2R10 antibody detects Taste receptor type 2 member 10, a G protein-coupled receptor (GPCR) encoded by the TAS2R10 gene located on chromosome 12p13.2. TAS2R10 belongs to the bitter taste receptor family and is primarily responsible for detecting bitter compounds in the oral cavity, but it is also expressed in extraoral tissues including airway epithelium, gastrointestinal tract, and immune cells. These broader expression patterns indicate additional roles in innate immunity, smooth muscle regulation, and metabolic signaling.\u003cbr\u003e\u003cbr\u003eTAS2R10 is a seven-transmembrane receptor that binds structurally diverse bitter ligands and activates intracellular signaling via gustducin or Galpha subunits. Ligand binding leads to activation of phospholipase C beta 2 (PLCB2), production of inositol trisphosphate (IP3), and release of calcium from intracellular stores. This signaling cascade triggers neuronal depolarization and perception of bitterness. In non-gustatory tissues, TAS2R10 signaling influences ciliary motility, bronchodilation, and antimicrobial peptide secretion. Known ligands include denatonium benzoate, quinine, and brucine.\u003cbr\u003e\u003cbr\u003eStructurally, TAS2R10 contains seven alpha-helical transmembrane domains, three extracellular loops for ligand recognition, and a cytoplasmic tail that interacts with G proteins. It belongs to the class A rhodopsin-like GPCR family, which mediates diverse sensory and hormonal signals. TAS2R10 is part of the taste receptor type 2 (T2R) subfamily, which includes approximately 25 functional bitter receptors in humans. Co-localization studies show TAS2R10 present in taste buds, bronchial cilia, and intestinal enteroendocrine cells, reflecting its multifunctional physiological roles.\u003cbr\u003e\u003cbr\u003eFunctionally, TAS2R10 contributes to gustatory perception as well as airway and gastrointestinal physiology. In airway smooth muscle, activation of TAS2R10 induces relaxation through localized calcium signaling, helping to counteract bronchoconstriction. In the gastrointestinal tract, it modulates hormone release and gut motility. TAS2R10 also contributes to innate immune defense by detecting bacterial metabolites and triggering ciliary clearance mechanisms in respiratory epithelium. During development, TAS2R10 expression appears after taste bud differentiation, coinciding with sensory nerve maturation.\u003cbr\u003e\u003cbr\u003eDysregulation or genetic variation in TAS2R10 may influence taste perception, dietary preferences, and susceptibility to airway diseases. Polymorphisms affecting receptor sensitivity are linked to interindividual differences in bitter compound detection. Pathway associations include GPCR signaling, calcium mobilization, and innate immune responses. In pharmacological research, TAS2R10 is being studied for its potential in bronchodilator and metabolic regulation therapies.\u003cbr\u003e\u003cbr\u003eThe TAS2R10 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TAS2R10 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TAS2R10 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TAS2R10 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TAS2R10 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TAS2R10+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047323066733,"sku":"FY13362","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_bb22f410-7996-4aa2-9ccf-4d5061e73d37.jpg?v=1782237104","url":"https:\/\/www.ebiohippo.com\/products\/tas2r10-antibody-taste-receptor-type-2-member-10-bha17136264","provider":"BioHippo","version":"1.0","type":"link"}