{"product_id":"tau-441-2n4r-p301s-mutant-monomers-bhp11901245","title":"Tau-441 (2N4R) P301S Mutant Monomers","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTau\u003c\/strong\u003e is provided as a recombinant protein reagent for \u003cstrong\u003eresearch use only\u003c\/strong\u003e. It is commonly used as a defined molecular component in biochemical and cell-free systems where controlled protein input supports mechanistic study and assay development.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProtein identity context:\u003c\/strong\u003e Tau (source species: Human).\u003c\/p\u003e\u003cp\u003eHuman Recombinant Tau-441 (2N4R) P301S Mutant Monomers (CHO-expressed, N-glycosylated)\u003c\/p\u003e\u003cp\u003eField of Use\u003c\/p\u003e\u003ch2\u003eBiological significance and function\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eTau\u003c\/strong\u003e is used in RUO research to interrogate molecular mechanisms, interaction networks, and pathway-linked phenotypes in experimental systems. This protein is frequently discussed in research themes such as \u003cstrong\u003eNeuroscience\u003c\/strong\u003e and \u003cstrong\u003eNeurodegeneration\u003c\/strong\u003e.\u003c\/p\u003e\u003ch2\u003eMolecular characteristics\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eMolecular characteristics:\u003c\/strong\u003e Key molecular attributes can influence binding behavior, stability, and assay background—especially for multimeric, disulfide-rich, or PTM-dependent proteins.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource species:\u003c\/strong\u003e Human\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtein length:\u003c\/strong\u003e 441 aa (excluding tag), 466 aa (including tag)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtein size:\u003c\/strong\u003e 48.609 kDa\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression system:\u003c\/strong\u003e Chinese Hamster Ovary (CHO)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurification:\u003c\/strong\u003e Affinity Purified and Size Exclusion\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage buffer:\u003c\/strong\u003e 1X PB pH 7.4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAffinity tag (sequence-indicated):\u003c\/strong\u003e His-tag\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003ePost-translational considerations:\u003c\/strong\u003e Mammalian expression can support native-like folding, disulfide bond formation, and glycosylation. These features are often important for secreted proteins, receptors, and adhesion molecules where PTMs influence binding and stability.\u003c\/p\u003e\u003ch2\u003eExpression and purification strategy\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eExpression system:\u003c\/strong\u003e Chinese Hamster Ovary (CHO). Expression host choice can influence folding and PTM state, which may affect binding or activity depending on protein class.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePurification strategy:\u003c\/strong\u003e Affinity Purified and Size Exclusion. Purification method and formulation help determine sample homogeneity and background in downstream biochemical assays.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTagging:\u003c\/strong\u003e The provided sequence suggests a \u003cstrong\u003eHis-tag\u003c\/strong\u003e, which can simplify capture\/immobilization workflows in binding assays. Tag status can also influence complex formation in some contexts.\u003c\/p\u003e\u003ch2\u003eResearch interpretation\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003eResearch interpretation:\u003c\/strong\u003e Recombinant protein reagents can support controlled experiments such as reconstitution of molecular interactions, quantitative calibration, and mechanistic perturbation studies with defined inputs. Interpreting outcomes typically benefits from pairing the primary readout with orthogonal markers that report on pathway state, localization, and complex formation.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug","offer_id":53016296456557,"sku":"SPR-515B","price":545.0,"currency_code":"USD","in_stock":true},{"title":"100 ug x 2","offer_id":53016296489325,"sku":"SPR-515C","price":980.0,"currency_code":"USD","in_stock":true},{"title":"100 ug x 5","offer_id":53016296522093,"sku":"SPR-515E","price":2035.0,"currency_code":"USD","in_stock":true},{"title":"500 ug (@5 mg\/ml)","offer_id":53016296554861,"sku":"SPR-515XE","price":2035.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPR-515_Tau-441-2N4R-P301S-Mutant-Monomers-CHO-expressed-N-glycosylated-Protein-SDS-Page-1.png?v=1770644839","url":"https:\/\/www.ebiohippo.com\/products\/tau-441-2n4r-p301s-mutant-monomers-bhp11901245","provider":"BioHippo","version":"1.0","type":"link"}