{"product_id":"tau-antibody-bha11933355","title":"Tau Antibody","description":"\u003cp\u003eTau is a microtubule-associated protein predominantly found in neuronal axons, where it stabilizes microtubules and supports axonal transport. In the adult human brain, six isoforms of tau are expressed, generated by alternative splicing of the MAPT gene. These isoforms contain either three (3R) or four (4R) microtubule-binding repeat domains, with 2N4R (Tau-441) representing the full-length form.\u003c\/p\u003e\n\n\u003cp\u003eIn healthy neurons, tau is tightly regulated. However, in neurodegenerative diseases known as tauopathies—including Alzheimer’s disease (AD), frontotemporal dementia, and progressive supranuclear palsy—tau becomes abnormally hyperphosphorylated. This modification reduces its affinity for microtubules, leading to the formation of insoluble neurofibrillary tangles (NFTs), a pathological hallmark of AD.\u003c\/p\u003e\n\n\u003cp\u003eMutations in the MAPT gene, such as P301S (encoded by exon 10), impair tau’s ability to bind microtubules and promote aggregation. These mutations are commonly used in transgenic models to study tau-mediated neurotoxicity, synaptic dysfunction, and neuronal death.\u003c\/p\u003e\n\n\u003cp\u003eTau pathology correlates strongly with cognitive decline in AD and is increasingly recognized as a driver of disease progression. As such, tau is a major focus of biomarker development and therapeutic targeting in neurodegenerative research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040796303725,"sku":"SMC-607D","price":401.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040899785069,"sku":"SMC-607D-A390","price":456.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040899817837,"sku":"SMC-607D-A488","price":455.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040899850605,"sku":"SMC-607D-A594","price":455.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040899883373,"sku":"SMC-607D-APC","price":453.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040899916141,"sku":"SMC-607D-BI","price":450.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040899948909,"sku":"SMC-607D-FITC","price":446.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040899981677,"sku":"SMC-607D-HRP","price":441.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040900014445,"sku":"SMC-607D-PCP","price":453.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040900047213,"sku":"SMC-607D-RPE","price":451.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040900079981,"sku":"SMC-607S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-607_Tau_Antibody_1D5_ICC-IF_Human_iPSC-derived-neurons_1.png?v=1771832170","url":"https:\/\/www.ebiohippo.com\/products\/tau-antibody-bha11933355","provider":"BioHippo","version":"1.0","type":"link"}