{"product_id":"tau-antibody-pser202-pthr205-bha11933283","title":"RECOMBINANT Tau Antibody (pSer202\/ pThr205)","description":"\u003cp\u003eTau is a microtubule-associated protein that plays a critical role in stabilizing neuronal microtubules and maintaining axonal integrity. In healthy neurons, tau is tightly regulated; however, in neurodegenerative diseases such as Alzheimer’s disease (AD), tau becomes abnormally hyperphosphorylated, leading to the formation of neurofibrillary tangles (NFTs).\u003c\/p\u003e\n\n\u003cp\u003ePhosphorylation at serine 202 and threonine 205 (pSer202\/pThr205) is a well-characterized early marker of pathological tau. This dual phosphorylation induces a conformational change in tau, promoting its detachment from microtubules and facilitating aggregation into insoluble fibrils. These aggregates disrupt neuronal function and are strongly correlated with cognitive decline in AD.\u003c\/p\u003e\n\n\u003cp\u003eThe pSer202\/pThr205 epitope is recognized by the widely used AT8 antibody, as well as by SMC-601, making it a critical biomarker for both research and diagnostic applications. Detection of this epitope is commonly used in histopathological studies and in the development of tau-targeted therapeutics.\u003c\/p\u003e\n\n\u003cp\u003eGiven its specificity for early tau pathology, pSer202\/pThr205 is a focal point in the study of tauopathies and a promising target for therapeutic intervention and biomarker development in neurodegenerative disease research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040796074349,"sku":"SMC-601D","price":487.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040896835949,"sku":"SMC-601D-A390","price":541.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040896868717,"sku":"SMC-601D-A488","price":540.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040896901485,"sku":"SMC-601D-A594","price":540.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040896934253,"sku":"SMC-601D-APC","price":539.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040896967021,"sku":"SMC-601D-BI","price":536.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040896999789,"sku":"SMC-601D-FITC","price":530.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040897032557,"sku":"SMC-601D-HRP","price":526.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040897065325,"sku":"SMC-601D-PCP","price":539.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040897098093,"sku":"SMC-601D-RPE","price":537.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040897130861,"sku":"SMC-601S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-601_Tau_Antibody_AH36_ICC-IF_Human_iPSC-derived-cortical-excitatory-neurons_1.png?v=1771832171","url":"https:\/\/www.ebiohippo.com\/products\/tau-antibody-pser202-pthr205-bha11933283","provider":"BioHippo","version":"1.0","type":"link"}