{"product_id":"tbkbp1-antibody-tank-binding-kinase-1-binding-protein-1-bha17136192","title":"TBKBP1 Antibody \/ TANK-binding kinase 1-binding protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTBKBP1 Antibody \/ TANK-binding kinase 1-binding protein 1 is a anti-TBKBP1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TBKBP1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTBKBP1 antibody recognizes TANK-binding kinase 1-binding protein 1, a scaffold protein that links TANK-binding kinase 1 (TBK1) and IKK epsilon to downstream effectors in antiviral and inflammatory signaling pathways. Encoded by the TBKBP1 gene, also known as SINTBAD (Similar to NAP1 TBK1 adaptor), this cytosolic adaptor protein participates in type I interferon responses by coordinating the assembly of signaling complexes involved in innate immunity. TBKBP1 interacts with kinases TBK1 and IKK epsilon to facilitate activation of interferon regulatory factors IRF3 and IRF7, leading to production of antiviral cytokines.\u003cbr\u003e\u003cbr\u003eTBKBP1 functions as part of a network of adaptor proteins, including NAP1 and TANK, that integrate pattern recognition receptor (PRR) signaling from Toll-like receptors, RIG-I-like receptors, and cytosolic DNA sensors. Upon pathogen detection, TBKBP1 recruits TBK1 to perinuclear regions and promotes its activation via phosphorylation. This process is essential for host defense against viral infection. Beyond immune responses, TBKBP1 also participates in autophagy regulation and may influence NF-kappaB signaling, linking innate immune sensing with cell survival and metabolic adaptation.\u003cbr\u003e\u003cbr\u003eThe TBKBP1 gene is located on chromosome 17q21.31 and encodes a protein with coiled-coil and leucine zipper domains that mediate multimeric complex formation. Expression is observed in immune tissues, liver, and lung, and can be induced by viral infection or interferon stimulation. Structural studies suggest that TBKBP1 provides a flexible scaffold for recruitment of kinases and transcription factors, enabling precise control of signal propagation. Genetic studies have associated TBKBP1 polymorphisms with autoimmune disorders and susceptibility to chronic inflammation.\u003cbr\u003e\u003cbr\u003eImmunohistochemical analysis using TBKBP1 antibody reveals cytoplasmic distribution in macrophages, dendritic cells, and epithelial tissues. The antibody is widely used to study antiviral defense mechanisms, cytokine signaling, and innate immune regulation. TBKBP1 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TBKBP1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TBKBP1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TBKBP1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TBKBP1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TBKBP1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047320969581,"sku":"FY13290","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_794493b8-4a7c-490c-ac66-9f1182e0c8b5.jpg?v=1782237080","url":"https:\/\/www.ebiohippo.com\/products\/tbkbp1-antibody-tank-binding-kinase-1-binding-protein-1-bha17136192","provider":"BioHippo","version":"1.0","type":"link"}