{"product_id":"tcea1-antibody-transcription-elongation-factor-a-protein-1-bha17136242","title":"TCEA1 Antibody \/ Transcription elongation factor A protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTCEA1 Antibody \/ Transcription elongation factor A protein 1 is a anti-TCEA1 Rabbit antibody Recombinant Rabbit Monoclonal clone 29T88 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP) with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TCEA1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29T88, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, IP\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTCEA1 antibody detects Transcription elongation factor A protein 1, encoded by the TCEA1 gene. Transcription elongation factor A protein 1 is a key regulator of RNA polymerase II transcriptional elongation and RNA processing. TCEA1 antibody provides researchers with a specific reagent to study transcriptional control, gene expression regulation, and cellular responses to DNA damage.\u003cbr\u003e\u003cbr\u003eTranscription elongation factor A protein 1 enhances the activity of RNA polymerase II by stimulating transcript elongation and resolving transcriptional arrest. Research using TCEA1 antibody has shown that it acts as a transcriptional cofactor by interacting with paused polymerase complexes and promoting the resumption of RNA synthesis. This activity ensures efficient transcription of protein coding genes, supporting diverse cellular processes including growth, proliferation, and differentiation.\u003cbr\u003e\u003cbr\u003eStudies with TCEA1 antibody have revealed that this factor also contributes to transcription coupled DNA repair. When RNA polymerase II encounters DNA damage, TCEA1 facilitates backtracking of the polymerase, enabling access for repair enzymes. This role links transcriptional regulation with genome stability and provides a mechanism for protecting cells from genotoxic stress. Dysregulation of this pathway may impair DNA repair capacity and promote disease development.\u003cbr\u003e\u003cbr\u003eBeyond transcriptional elongation, Transcription elongation factor A protein 1 influences chromatin remodeling. Research using TCEA1 antibody has demonstrated that it cooperates with other transcriptional cofactors to modify chromatin architecture, enhancing promoter clearance and elongation efficiency. This highlights its integration into a broader regulatory network that coordinates transcription with chromatin state.\u003cbr\u003e\u003cbr\u003eDysregulation of TCEA1 expression has been implicated in cancer and neurological disease. Studies with TCEA1 antibody have shown that altered levels can disrupt transcription fidelity, impair DNA repair, and promote genomic instability. Overexpression in some cancers may provide tumor cells with enhanced transcriptional capacity, while deficiencies have been linked to neurodegeneration. These findings underscore its importance in both health and pathology.\u003cbr\u003e\u003cbr\u003eTCEA1 antibody is commonly applied in western blotting, immunohistochemistry, and chromatin immunoprecipitation. Western blotting detects protein expression levels, immunohistochemistry reveals nuclear localization in tissue, and chromatin immunoprecipitation maps binding to actively transcribed genes. These applications make TCEA1 antibody indispensable for transcription biology research.\u003cbr\u003e\u003cbr\u003eBy supplying validated TCEA1 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TCEA1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TCEA1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TCEA1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TCEA1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TCEA1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047323591021,"sku":"FY13340","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c1741910-63af-47e4-884b-2c97827c6844.jpg?v=1772019429","url":"https:\/\/www.ebiohippo.com\/products\/tcea1-antibody-transcription-elongation-factor-a-protein-1-bha17136242","provider":"BioHippo","version":"1.0","type":"link"}