{"product_id":"tcn-201-bhb21300344","title":"TCN 201","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e N-[[4-(benzamidocarbamoyl)phenyl]methyl]-3-chloro-4-fluorobenzenesulfonamide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e QCR-22\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 852918-02-6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C21H17ClFN3O4S.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.1-10 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NMDA receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e TCN 201 blocks NR1\/NR2A NMDA receptors in an NR1 co-agonist dependent and non-competitive manner1, selective for NR2A- over NR2B-containing receptors, with pIC50 of 6.8 on human recombinant NR1\/NR2A in FLIPR\/Ca2+ assay2.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e QCR-22\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eTCN 201, a sulphonamide derivative, acts as a selective and potent NMDA (methyl-D-aspartate) receptor antagonist. This compound displays a high selectivity for GluN1\/GluN2A-containing NMDAR receptors over GluN1\/GluN2B containing receptors and acts in a non-competitive manner. The degree of its antagonism is dependent on the concentration of the GluN1-site co-agonist, glycine or D-serine, and is independent of the glutamate concentration1. TCN 201 can be used to estimate and to clarify the contribution of NMDAR subunit and its composition and function.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2\/GluN3 subunits. NMDAR plays an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke. NMDA receptors mediate physiological functions such as learning and memory formation. They play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease2.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249714323821,"sku":"T-190-10MG-1","price":85.0,"currency_code":"USD","in_stock":true},{"title":"100 mg \/ 1","offer_id":53311578800493,"sku":"T-190-100MG-1","price":603.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311578833261,"sku":"T-190-25MG-1","price":184.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311578866029,"sku":"T-190-5MG-1","price":66.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311578898797,"sku":"T-190-50MG-1","price":337.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/T-190_gr.gif?v=1778544458","url":"https:\/\/www.ebiohippo.com\/products\/tcn-201-bhb21300344","provider":"BioHippo","version":"1.0","type":"link"}