{"product_id":"tdrd9-antibody-tudor-domain-containing-protein-9-bha17136030","title":"TDRD9 Antibody \/ Tudor domain-containing protein 9","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTDRD9 Antibody \/ Tudor domain-containing protein 9 is a anti-TDRD9 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TDRD9\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTDRD9 antibody detects Tudor domain-containing protein 9, an ATP-dependent RNA helicase that plays a crucial role in the piRNA pathway and germline genome defense. The UniProt recommended name is Tudor domain-containing protein 9 (TDRD9). This protein is a key component of the PIWI-interacting RNA (piRNA) silencing machinery, which suppresses transposable elements during spermatogenesis to maintain genomic integrity.\u003cbr\u003e\u003cbr\u003eFunctionally, TDRD9 antibody identifies a 1,278-amino-acid protein containing a C-terminal helicase domain and an N-terminal Tudor domain. The Tudor domain recognizes methylated arginine residues on PIWI proteins, while the helicase domain unwinds RNA substrates during piRNA amplification. TDRD9 forms complexes with MIWI2 and other germline-specific proteins to silence retrotransposons through DNA methylation and RNA degradation.\u003cbr\u003e\u003cbr\u003eThe TDRD9 gene is located on chromosome 14q21.1 and is expressed predominantly in male germ cells during spermatogenesis. It is localized to the cytoplasmic nuage and intermitochondrial cement structures in developing spermatocytes. TDRD9 activity ensures transposon repression and proper germ cell development.\u003cbr\u003e\u003cbr\u003ePathologically, mutations in TDRD9 cause non-obstructive azoospermia and male infertility due to germline arrest and failure of transposon silencing. Dysregulation of TDRD9 or the piRNA pathway may also contribute to germ cell tumors and epigenetic instability. Research using TDRD9 antibody supports studies in germline biology, RNA regulation, and epigenetic silencing.\u003cbr\u003e\u003cbr\u003eTDRD9 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect germline helicases and piRNA pathway components. \u003cbr\u003e\u003cbr\u003eStructurally, Tudor domain-containing protein 9 contains conserved helicase motifs typical of the DEXD\/H-box family and a Tudor domain that mediates protein-RNA interactions. This antibody enables investigation of TDRD9's molecular functions in piRNA biogenesis and transposon repression.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TDRD9 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TDRD9 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TDRD9 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TDRD9 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TDRD9+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047313170797,"sku":"FY13128","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ab0f8ca2-eda6-4abf-b5f0-0dbad37ae764.jpg?v=1782237109","url":"https:\/\/www.ebiohippo.com\/products\/tdrd9-antibody-tudor-domain-containing-protein-9-bha17136030","provider":"BioHippo","version":"1.0","type":"link"}