{"product_id":"tenm2-antibody-teneurin-2-bha17135620","title":"TENM2 Antibody \/ Teneurin 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTENM2 Antibody \/ Teneurin 2 is a anti-TENM2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Immunohistochemistry (IHC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human. Reported localization: Cytoplasm, cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TENM2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTENM2 antibody detects Teneurin-2 (also known as Ten-m homolog 2 or Odz2), a large type II transmembrane protein that mediates cell adhesion, axon guidance, and synaptic organization. Encoded by the TENM2 gene on chromosome 5q34, this protein is part of the teneurin family of evolutionarily conserved signaling molecules involved in neural patterning and intercellular communication. Teneurin-2 contains an N-terminal intracellular domain, a single transmembrane region, and a large extracellular domain with EGF-like repeats, YD repeats, and a C-terminal teneurin domain that supports homophilic and heterophilic interactions. Through these structural features, TENM2 contributes to neuronal connectivity, synapse formation, and tissue patterning during development.\u003cbr\u003e\u003cbr\u003eTeneurin-2 is expressed in the developing central nervous system, retina, and various non-neuronal tissues such as lung and kidney. It promotes target-specific synaptic connections by interacting with latrophilins (LPHN family GPCRs), forming trans-synaptic complexes that regulate synapse specificity. The intracellular domain of TENM2 can be proteolytically cleaved and translocated to the nucleus, where it may function in transcriptional regulation. In addition to neural roles, TENM2 contributes to epithelial organization, cellular differentiation, and tissue morphogenesis. Disruption of teneurin signaling is linked to neurodevelopmental disorders and certain cancers.\u003cbr\u003e\u003cbr\u003eThe TENM2 antibody is widely used in neuroscience, developmental biology, and oncology research to study teneurin-mediated adhesion and signaling. Western blot analysis identifies a high molecular weight band (~300 kilodaltons) corresponding to full-length TENM2, while immunohistochemistry and immunofluorescence show membrane and perinuclear localization. In neurons, TENM2 expression defines specific circuits, including visual and hippocampal pathways. In tumors, altered expression correlates with changes in adhesion and metastasis potential. The TENM2 antibody allows researchers to investigate teneurin signaling networks that govern tissue connectivity and growth regulation.\u003cbr\u003e\u003cbr\u003eTENM2 interacts with extracellular matrix proteins and other teneurins to guide axonal targeting and tissue patterning. Its cytoplasmic domain contains phosphorylation motifs suggesting regulatory crosstalk with intracellular kinases. Loss or mutation of TENM2 disrupts normal neuronal wiring and has been associated with autism spectrum disorder and intellectual disability. Because of these diverse functions, the TENM2 antibody is an essential reagent for mapping teneurin distribution and understanding its developmental and pathological roles.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TENM2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TENM2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TENM2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TENM2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TENM2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047297802605,"sku":"FY12717","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c6ec78d0-476a-401e-8d33-f60ebd970556.jpg?v=1782237041","url":"https:\/\/www.ebiohippo.com\/products\/tenm2-antibody-teneurin-2-bha17135620","provider":"BioHippo","version":"1.0","type":"link"}