{"product_id":"tgfb1-antibody-transforming-growth-factor-beta-1-bha17135287","title":"TGFB1 Antibody \/ Transforming growth factor beta-1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTGFB1 Antibody \/ Transforming growth factor beta-1 is a anti-TGFB1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TGFB1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe TGFB1 antibody targets Transforming growth factor beta-1, a multifunctional cytokine encoded by the TGFB1 gene that regulates cell growth, differentiation, immune response, and extracellular matrix production. As a member of the TGF-beta superfamily, this secreted protein plays pivotal roles in development, tissue repair, and immune regulation. Transforming growth factor beta-1 is synthesized as a latent precursor that undergoes proteolytic activation to yield the mature cytokine. The TGFB1 antibody provides researchers with a reliable reagent to study this crucial signaling molecule and its diverse biological effects.\u003cbr\u003e\u003cbr\u003eTransforming growth factor beta-1 binds to type I and type II TGF-beta receptors, initiating phosphorylation of SMAD transcription factors that regulate gene expression. This signaling pathway influences processes such as epithelial-to-mesenchymal transition (EMT), fibrosis, angiogenesis, and immune tolerance. The TGFB1 antibody enables quantification of protein levels and distribution in tissues, helping elucidate how this cytokine coordinates cellular communication during development and wound healing.\u003cbr\u003e\u003cbr\u003eDysregulated TGF-beta1 signaling contributes to numerous diseases, including cancer, pulmonary fibrosis, liver cirrhosis, and autoimmune disorders. Overproduction drives fibrotic remodeling through excessive extracellular matrix deposition, while loss of function can impair immune suppression and tissue homeostasis. The TGFB1 antibody is a critical tool for analyzing these disease mechanisms, allowing assessment of active and latent forms of the cytokine. It is widely used in immunohistochemical detection of TGF-beta1 expression in fibrotic lesions, tumors, and inflamed tissues.\u003cbr\u003e\u003cbr\u003eIn cancer, Transforming growth factor beta-1 exhibits dual roles�acting as a tumor suppressor in early stages and a tumor promoter in advanced disease. It enhances epithelial cell migration and invasion by inducing EMT and modifying the tumor microenvironment. The TGFB1 antibody allows researchers to explore these context-dependent effects, providing insight into how TGF-beta1 transitions from growth inhibitory to pro-metastatic functions. In immunology, this cytokine maintains peripheral tolerance by inducing regulatory T cells and suppressing inflammatory responses.\u003cbr\u003e\u003cbr\u003eThe TGFB1 antibody performs effectively in western blotting, ELISA, and immunohistochemistry. It provides robust detection of both precursor and mature forms of Transforming growth factor beta-1.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TGFB1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TGFB1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TGFB1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TGFB1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TGFB1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047287906669,"sku":"FY12384","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5c177605-bb44-4ab8-bb4e-4ac6341759b2.jpg?v=1782237004","url":"https:\/\/www.ebiohippo.com\/products\/tgfb1-antibody-transforming-growth-factor-beta-1-bha17135287","provider":"BioHippo","version":"1.0","type":"link"}