{"product_id":"tgfbi-antibody-transforming-growth-factor-beta-induced-protein-ig-h3-bha17135309","title":"TGFBI Antibody \/ Transforming growth factor-beta-induced protein ig-h3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTGFBI Antibody \/ Transforming growth factor-beta-induced protein ig-h3 is a anti-TGFBI Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TGFBI\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe TGFBI antibody targets Transforming growth factor-beta-induced protein ig-h3, a secreted extracellular matrix protein encoded by the TGFBI gene. Induced by TGF-beta signaling, this protein plays critical roles in cell adhesion, migration, and matrix organization. Transforming growth factor-beta-induced protein ig-h3 contains multiple fasciclin domains that mediate interactions with integrins and collagen, promoting tissue integrity and repair. The TGFBI antibody provides a valuable tool for studying extracellular signaling, wound healing, and fibrotic disease mechanisms.\u003cbr\u003e\u003cbr\u003eTransforming growth factor-beta-induced protein ig-h3 is secreted into the extracellular space, where it binds integrins such as alphavbeta3 and alpha3beta1 to regulate adhesion and cell-matrix communication. It is widely expressed in corneal, epithelial, and connective tissues. The TGFBI antibody allows visualization of its distribution and quantification under TGF-beta stimulation, providing insight into how this protein orchestrates matrix remodeling. Its RGD motif facilitates integrin binding, influencing cell attachment, migration, and differentiation.\u003cbr\u003e\u003cbr\u003eMutations in the TGFBI gene cause a spectrum of hereditary corneal dystrophies, including granular, lattice, and Avellino types, characterized by amyloid or hyaline deposits in the cornea. The TGFBI antibody supports studies into these pathologies, enabling detection of protein accumulation and abnormal deposition patterns. By tracking misfolded Transforming growth factor-beta-induced protein ig-h3, researchers can better understand disease progression and potential therapeutic interventions aimed at preventing protein aggregation.\u003cbr\u003e\u003cbr\u003eBeyond ocular disease, TGFBI is implicated in cancer, fibrosis, and tissue regeneration. It may function as either a tumor suppressor or promoter depending on context, influencing epithelial-to-mesenchymal transition (EMT) and extracellular matrix stiffness. The TGFBI antibody supports exploration of these dual roles by enabling quantification of expression levels in tumor microenvironments and fibrotic tissues. TGFBI overexpression is associated with enhanced metastasis in certain cancers, making it a potential biomarker for disease progression.\u003cbr\u003e\u003cbr\u003eThe TGFBI antibody performs well in western blotting, immunohistochemistry, and immunofluorescence, showing distinct extracellular and pericellular staining consistent with matrix localization.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TGFBI - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TGFBI - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TGFBI - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TGFBI - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TGFBI+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047287710061,"sku":"FY12406","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_93daf615-a464-4a7e-a296-f44fd67bf352.jpg?v=1782237002","url":"https:\/\/www.ebiohippo.com\/products\/tgfbi-antibody-transforming-growth-factor-beta-induced-protein-ig-h3-bha17135309","provider":"BioHippo","version":"1.0","type":"link"}