{"product_id":"tgoln2-antibody-trans-golgi-network-integral-membrane-protein-2-bha17135328","title":"TGOLN2 Antibody \/ Trans-Golgi network integral membrane protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTGOLN2 Antibody \/ Trans-Golgi network integral membrane protein 2 is a anti-TGOLN2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TGOLN2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe TGOLN2 antibody targets Trans-Golgi network integral membrane protein 2, also known as TGN46, encoded by the TGOLN2 gene. This type I transmembrane glycoprotein localizes to the trans-Golgi network (TGN), where it participates in protein sorting, trafficking, and recycling between the Golgi apparatus and endosomes. Trans-Golgi network integral membrane protein 2 acts as a marker of the TGN and is essential for maintaining Golgi structure and vesicle organization. The TGOLN2 antibody provides a robust reagent for studying Golgi dynamics, membrane transport, and secretory-pathway regulation.\u003cbr\u003e\u003cbr\u003eTrans-Golgi network integral membrane protein 2 cycles between the TGN and plasma membrane via clathrin-coated vesicles, controlling cargo retrieval and receptor recycling. Its luminal domain carries O-linked glycosylation sites that modulate trafficking efficiency. The TGOLN2 antibody allows visualization of this dynamic localization pattern, offering a reliable marker for confocal microscopy and subcellular fractionation studies. Its expression is ubiquitous in secretory cells, particularly in liver, pancreas, and neurons.\u003cbr\u003e\u003cbr\u003eTGN46 functions as a sorting receptor for a subset of secreted and membrane proteins, ensuring their correct targeting to the cell surface or lysosomes. The TGOLN2 antibody supports mechanistic research into Golgi transport, revealing how membrane trafficking contributes to cellular polarity and secretion. Through its cytoplasmic tail, TGN46 interacts with adaptor protein complexes (AP-1 and GGA), linking it to clathrin-mediated sorting pathways.\u003cbr\u003e\u003cbr\u003eAberrant Golgi organization is a hallmark of many diseases, including neurodegenerative disorders and cancers. The TGOLN2 antibody is widely used as a Golgi marker in pathology and cell-biology research, helping identify structural changes associated with altered vesicular transport. Changes in TGN46 distribution can reflect stress-induced fragmentation or disrupted trafficking in diseased cells.\u003cbr\u003e\u003cbr\u003eThe TGOLN2 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, yielding strong perinuclear staining that defines Golgi morphology.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TGOLN2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TGOLN2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TGOLN2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TGOLN2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TGOLN2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047286759789,"sku":"FY12425","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_3e830c79-899d-4fcd-b738-9124625d056d.jpg?v=1782236985","url":"https:\/\/www.ebiohippo.com\/products\/tgoln2-antibody-trans-golgi-network-integral-membrane-protein-2-bha17135328","provider":"BioHippo","version":"1.0","type":"link"}