{"product_id":"thyn1-antibody-thymocyte-nuclear-protein-1-bha17135783","title":"THYN1 Antibody \/ Thymocyte nuclear protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTHYN1 Antibody \/ Thymocyte nuclear protein 1 is a anti-THYN1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow cytometry (FACS), ELISA with listed reactivity in Human. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e THYN1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, IP, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTHYN1 antibody detects Thymocyte nuclear protein 1, a nuclear DNA-binding protein that plays a role in apoptosis regulation, lymphocyte differentiation, and chromatin organization. Encoded by the THYN1 gene on chromosome 11q25, this evolutionarily conserved protein is predominantly expressed in thymocytes and lymphoid tissues, where it contributes to T-cell maturation and apoptotic signaling. THYN1 is also found in other proliferative cell types, indicating a broader role in cell cycle regulation and genomic stability.\u003cbr\u003e\u003cbr\u003eStructurally, Thymocyte nuclear protein 1 is a 225-amino-acid protein of approximately 26 kilodaltons that localizes to the nucleus. It contains multiple lysine and arginine-rich regions that facilitate DNA interaction and chromatin association, as well as nuclear localization sequences that ensure retention within the nucleus. Its precise molecular function remains under study, but evidence suggests that THYN1 participates in apoptotic chromatin condensation and transcriptional control during cell stress and differentiation.\u003cbr\u003e\u003cbr\u003eThe THYN1 antibody is widely used in immunology, apoptosis, and hematopoiesis research to study nuclear regulation of T-cell development and programmed cell death. Western blot analysis detects a band at approximately 28 kilodaltons corresponding to THYN1, while immunofluorescence demonstrates nuclear punctate staining consistent with chromatin association. This antibody is a valuable tool for understanding nuclear protein dynamics in immune cell differentiation and apoptosis signaling.\u003cbr\u003e\u003cbr\u003eFunctionally, THYN1 has been linked to regulation of the apoptotic pathway through interactions with caspase-dependent DNA fragmentation processes. Its expression is highest in thymocytes undergoing negative selection, suggesting a role in eliminating autoreactive T-cells. Beyond immune regulation, THYN1 may contribute to chromatin remodeling and transcriptional repression during stress-induced cell cycle arrest. Dysregulation of THYN1 has been associated with cancer cell survival and abnormal immune function, underscoring its potential role in tumor immunology and apoptosis resistance. The THYN1 antibody supports investigations into nuclear apoptosis mechanisms and T-cell homeostasis.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=THYN1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=THYN1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=THYN1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/THYN1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=THYN1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047304749421,"sku":"FY12881","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f6255d81-2fef-448d-93b5-a6839b29983e.jpg?v=1782237053","url":"https:\/\/www.ebiohippo.com\/products\/thyn1-antibody-thymocyte-nuclear-protein-1-bha17135783","provider":"BioHippo","version":"1.0","type":"link"}