{"product_id":"thz-p1-2-bhb20427896","title":"THZ-P1-2","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n  \u003ch2\u003eCompound Overview\u003c\/h2\u003e\n  \u003cp\u003e\u003cstrong\u003eTHZ-P1-2\u003c\/strong\u003e (CAS 2058075-45-7) is a research-grade small molecule supplied by TargetMol.\u003c\/p\u003e\n\n  \u003ch2\u003ePhysical Properties\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eCAS Number\u003c\/th\u003e\n\u003ctd\u003e2058075-45-7\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Formula\u003c\/th\u003e\n\u003ctd\u003eC31H29N7O2\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e531.62 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eSMILES\u003c\/th\u003e\n\u003ctd style=\"font-size:13px;word-break:break-all\"\u003eCN(C)CC=CC(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2c(nH)c3ccccc23)c1\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eSolid\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eRoom Temperature (RT)\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n  \u003ch2\u003eBiological Activity\u003c\/h2\u003e\n  \u003cp\u003eTHZ-P1-2 is a novel, specific inhibitor of PI5P4K that effectively targets PI5P4Kalpha. With an IC 50 of 190 nM, THZ-P1-2 selectively inhibits PI5P4Kalpha by forming covalent bonds with cysteine residues located on a disordered loop present in PI5P4Kalpha\/beta\/gamma. This mechanism not only disrupts autophagy but also elevates TFEB signaling. Moreover, THZ-P1-2 exhibits potent anticancer effects in leukemia cell lines, making it a promising candidate for therapeutic applications.\u003c\/p\u003e\n  \u003ch2\u003eSafety \u0026amp; Regulatory\u003c\/h2\u003e\n  \u003cdiv class=\"bhp-warning-box\"\u003e\n    \u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.\u003c\/p\u003e\n  \u003c\/div\u003e\n\u003c\/div\u003e","brand":"TargetMol","offers":[{"title":"1 mg","offer_id":53327243805037,"sku":"T39459-1MG","price":68.0,"currency_code":"USD","in_stock":true},{"title":"2 mg","offer_id":53327328182637,"sku":"T39459-2MG","price":98.0,"currency_code":"USD","in_stock":true},{"title":"5 mg","offer_id":53327328215405,"sku":"T39459-5MG","price":163.0,"currency_code":"USD","in_stock":true},{"title":"1 mL x 10 mM (in DMSO)","offer_id":53327328248173,"sku":"T39459-1MLX10MM","price":192.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53327328280941,"sku":"T39459-10MG","price":228.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53327328313709,"sku":"T39459-25MG","price":368.0,"currency_code":"USD","in_stock":true},{"title":"50 mg","offer_id":53327328346477,"sku":"T39459-50MG","price":519.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53327328379245,"sku":"T39459-100MG","price":728.0,"currency_code":"USD","in_stock":true},{"title":"200 mg","offer_id":53327328412013,"sku":"T39459-200MG","price":983.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CgoaEGayN7-ESkUVAAAAAGPvARk217.png?v=1778722208","url":"https:\/\/www.ebiohippo.com\/products\/thz-p1-2-bhb20427896","provider":"BioHippo","version":"1.0","type":"link"}