{"product_id":"tiam1-antibody-t-cell-lymphoma-invasion-and-metastasis-1-bha17128178","title":"TIAM1 Antibody \/ T cell lymphoma invasion and metastasis 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eTIAM1 Antibody \/ T cell lymphoma invasion and metastasis 1 is an antibody targeting \u003cstrong\u003eTIAM1\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TIAM1.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eTIAM1 is a protein that plays a crucial role in cell migration and invasion. In T cell lymphoma, increased expression of TIAM1 has been associated with enhanced invasive capabilities of cancer cells. TIAM1 promotes the formation of invasive structures called invadopodia, which facilitate cancer cell movement through tissues. Additionally, TIAM1 has been shown to activate signaling pathways that promote metastasis, making it a key player in the spread of T cell lymphoma. Studies have demonstrated that targeting TIAM1 can inhibit T cell lymphoma invasion. By disrupting the activity of TIAM1, researchers have been able to reduce the ability of cancer cells to invade surrounding tissues. This suggests that TIAM1 could be a potential therapeutic target for inhibiting T cell lymphoma invasion and slowing down disease progression. Metastasis is a major concern in T cell lymphoma, as cancer cells can spread to distant organs and tissues, leading to poor prognosis. TIAM1 has been implicated in promoting the metastatic spread of T cell lymphoma cells. By targeting TIAM1, researchers have observed a decrease in the ability of cancer cells to metastasize, highlighting the potential of TIAM1 as a therapeutic target for preventing T cell lymphoma metastasis.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q13009 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q13009 - Gene search: TIAM1 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TIAM1 - Ensembl search: TIAM1 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TIAM1 - PubMed search: TIAM1 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TIAM1+antibody - Reactome search: TIAM1 — Reactome — https:\/\/reactome.org\/content\/query?q=TIAM1 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53046409003373,"sku":"F55115-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53046469263725,"sku":"F55115-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7ae7b3b4-e80f-4616-b8a6-0be27ee29697.jpg?v=1772000489","url":"https:\/\/www.ebiohippo.com\/products\/tiam1-antibody-t-cell-lymphoma-invasion-and-metastasis-1-bha17128178","provider":"BioHippo","version":"1.0","type":"link"}