{"product_id":"tmeff1-antibody-transmembrane-protein-with-egf-like-and-two-follistatin-like-domains-1-bha17136232","title":"TMEFF1 Antibody \/ Transmembrane protein with EGF-like and two follistatin-like domains 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTMEFF1 Antibody \/ Transmembrane protein with EGF-like and two follistatin-like domains 1 is a anti-TMEFF1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TMEFF1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTMEFF1 antibody detects Transmembrane protein with EGF-like and two follistatin-like domains 1, a single-pass transmembrane protein encoded by the TMEFF1 gene on chromosome 9p22.3. TMEFF1 is a cell surface glycoprotein belonging to the follistatin and EGF-like domain-containing family and is primarily expressed in the brain, prostate, and embryonic tissues. The protein localizes to the plasma membrane and participates in cell signaling, neurodevelopment, and tumor suppression. TMEFF1 contributes to neuronal differentiation and growth factor signaling modulation through interactions with growth factor receptors and extracellular matrix components.\u003cbr\u003e\u003cbr\u003eTMEFF1 functions as a modulator of transforming growth factor beta (TGF-beta) and EGF signaling pathways. It binds heparin and cell-surface glycosaminoglycans, influencing receptor activation and downstream cascades. In neurons, TMEFF1 promotes survival and neurite extension, suggesting a role in brain development and maintenance. It has also been reported to exhibit tumor-suppressive properties by inhibiting EGF receptor signaling and cell proliferation in certain cancers.\u003cbr\u003e\u003cbr\u003eStructurally, TMEFF1 contains an extracellular region with one epidermal growth factor (EGF)-like domain and two follistatin-like (FS) domains, a transmembrane helix, and a short cytoplasmic tail. These extracellular domains mediate ligand interactions, including potential binding with follistatin and growth factors, while the cytoplasmic region may transmit regulatory signals to intracellular effectors. TMEFF1 belongs to the follistatin domain protein family, known for regulating growth and differentiation through modulation of TGF-beta superfamily ligands.\u003cbr\u003e\u003cbr\u003eTMEFF1 expression is most abundant in neurons, especially in the cerebellum, hippocampus, and olfactory bulb, indicating a role in neuronal connectivity and signaling. It is also detected in epithelial tissues of the prostate and testis. During development, TMEFF1 regulates neurogenesis and may act as a neuronal adhesion molecule. Co-localization studies show TMEFF1 associating with EGFR and ErbB2 at the plasma membrane, modulating their activation and downstream MAPK and PI3K-AKT pathways.\u003cbr\u003e\u003cbr\u003eDysregulation of TMEFF1 is implicated in cancer progression. Reduced expression correlates with poor prognosis in glioma, gastric, and colorectal cancers. Conversely, overexpression can suppress tumor growth by inhibiting proliferation and promoting apoptosis. The gene's promoter region is often hypermethylated in tumors, leading to transcriptional silencing. Pathway involvement includes TGF-beta signaling, EGFR signaling, and cell adhesion pathways.\u003cbr\u003e\u003cbr\u003eTMEFF1 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TMEFF1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TMEFF1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TMEFF1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TMEFF1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TMEFF1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047324180845,"sku":"FY13330","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d8dee332-e608-415c-b6a5-fd4f68a3fc27.jpg?v=1782237108","url":"https:\/\/www.ebiohippo.com\/products\/tmeff1-antibody-transmembrane-protein-with-egf-like-and-two-follistatin-like-domains-1-bha17136232","provider":"BioHippo","version":"1.0","type":"link"}