{"product_id":"tmem201-antibody-transmembrane-protein-201-bha17135226","title":"TMEM201 Antibody \/ Transmembrane protein 201","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTMEM201 Antibody \/ Transmembrane protein 201 is a anti-TMEM201 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TMEM201\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTMEM201 Antibody is used to study Transmembrane protein 201, an inner nuclear membrane protein that helps organize the nuclear envelope and coordinate nucleus-to-cytoskeleton communication. Localized at the inner nuclear membrane, Transmembrane protein 201 interacts with elements of the LINC complex that connect nuclear lamins to actin cables, supporting nuclear positioning, cell polarization, and directed migration. By anchoring the nucleus to retrograde actin flow through transmembrane actin-associated nuclear lines, Transmembrane protein 201 influences how cells orient and move in response to external cues, a process relevant to development, wound repair, and vascular remodeling.\u003cbr\u003e\u003cbr\u003eBiochemically, Transmembrane protein 201 contains luminal and cytoplasmic regions that permit associations with lamins and cytoskeletal adaptors. These interactions help maintain nuclear envelope integrity and may tune mechanotransduction, allowing cells to translate mechanical forces into gene-regulatory outcomes. Perturbation of Transmembrane protein 201 can disrupt centrosome orientation and impair cell polarity, emphasizing its role at the interface of structure and signaling. In endothelial systems, increased Transmembrane protein 201 activity has been linked with enhanced migration during angiogenic sprouting, underscoring its relevance to vascular biology.\u003cbr\u003e\u003cbr\u003eResearchers use TMEM201 Antibody to define inner nuclear membrane architecture by immunofluorescence, co-localize the protein with lamins or SUN\/KASH components, and quantify expression under conditions that alter cytoskeletal tension. In immunoblotting, the antibody detects endogenous Transmembrane protein 201 and can monitor isoform abundance or post-translational changes across cell states. Immunoprecipitation with TMEM201 Antibody enables mapping of protein partners at the nuclear envelope, supporting studies that connect nuclear mechanics to transcriptional control and cell fate decisions. Because nuclear positioning and mechanosensitive signaling influence differentiation, immunity, and cancer invasion, this reagent supports a wide set of experimental questions.\u003cbr\u003e\u003cbr\u003eThe TMEM201 Antibody from \u003cbr\u003e\u003cbr\u003eAs interest grows in how nuclear architecture governs cell behavior, TMEM201 Antibody provides a practical bridge between nuclear envelope structure and systems-level outcomes. Its use in standard immunocytochemistry, tissue immunohistochemistry, and pulldown experiments makes it a versatile tool for dissecting nuclear positioning, mechanotransduction, and angiogenesis, while helping connect biophysical cues to gene regulation and phenotype in both normal physiology and disease contexts.\u003cbr\u003e\u003cbr\u003eTMEM201 Antibody supports rigorous inquiries into nuclear mechanics with a single, reliable probe that integrates cleanly into multicolor imaging, gel-based quantification, and interactome discovery workflows.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TMEM201 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TMEM201 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TMEM201 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TMEM201 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TMEM201+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047285154157,"sku":"FY12323","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5d0c4ef9-6299-475f-9b57-6b6c6581a67e.jpg?v=1782236985","url":"https:\/\/www.ebiohippo.com\/products\/tmem201-antibody-transmembrane-protein-201-bha17135226","provider":"BioHippo","version":"1.0","type":"link"}