{"product_id":"tmod1-antibody-tropomodulin-1-bha17135836","title":"TMOD1 Antibody \/ Tropomodulin 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTMOD1 Antibody \/ Tropomodulin 1 is a anti-TMOD1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TMOD1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IP, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTMOD1 antibody detects tropomodulin-1, a key actin filament capping protein that regulates the length and stability of actin filaments in muscle and non-muscle cells. The UniProt recommended name is Tropomodulin-1 (TMOD1), with alternate names erythrocyte tropomodulin, TMOD, and E-Tmod. TMOD1 binds to the pointed (minus) end of actin filaments, preventing actin polymerization or depolymerization and thereby maintaining precise filament lengths essential for cytoskeletal integrity and contractile function.\u003cbr\u003e\u003cbr\u003eIn striated muscle, TMOD1 antibody identifies the isoform predominantly expressed in cardiac and slow skeletal muscle fibers, where it associates with tropomyosin and actin at the pointed end of thin filaments. TMOD1 plays an important role in sarcomere organization, length control, and muscle elasticity. Deficiency or mutation of TMOD1 disrupts sarcomere alignment, leading to myofibrillar disarray and cardiomyopathy phenotypes. In non-muscle cells, TMOD1 is involved in maintaining cortical actin networks, cell shape, and motility, particularly in erythrocytes where it preserves membrane mechanical stability and deformability.\u003cbr\u003e\u003cbr\u003eTMOD1 antibody is used to study cytoskeletal architecture, cardiac muscle structure, and erythrocyte morphology. TMOD1 interacts with tropomyosin isoforms (TPM1-4) and capping proteins, coordinating actin filament dynamics during cell movement and myofibrillogenesis. In cardiac development, TMOD1 expression begins early in embryogenesis, highlighting its importance for contractile apparatus assembly. The TMOD1 gene, located on chromosome 9q22.33, encodes a 359-amino acid cytosolic protein that contains tropomyosin-binding and actin-capping domains. TMOD1 operates together with its isoforms TMOD2, TMOD3, and TMOD4, each showing tissue-specific distribution and regulatory mechanisms.\u003cbr\u003e\u003cbr\u003eAltered TMOD1 expression has been linked to dilated cardiomyopathy, hereditary spherocytosis, and various muscle weakness disorders. Research also suggests TMOD1's involvement in cell adhesion, migration, and neuronal growth cone dynamics. Detection with TMOD1 antibody in immunostaining and western blot analyses allows detailed exploration of its role in filament organization and cell morphology under normal and disease conditions.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TMOD1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TMOD1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TMOD1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TMOD1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TMOD1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047306781037,"sku":"FY12934","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a7549a69-f7e8-47a9-a4e4-bb3dce3f91d2.jpg?v=1782237056","url":"https:\/\/www.ebiohippo.com\/products\/tmod1-antibody-tropomodulin-1-bha17135836","provider":"BioHippo","version":"1.0","type":"link"}