{"product_id":"tmprss4-antibody-transmembrane-protease-serine-4-bha17135645","title":"TMPRSS4 Antibody \/ Transmembrane protease serine 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTMPRSS4 Antibody \/ Transmembrane protease serine 4 is a anti-TMPRSS4 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TMPRSS4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTMPRSS4 antibody detects Transmembrane protease serine 4, a cell surface serine protease implicated in epithelial differentiation, tissue remodeling, and cancer progression. Encoded by the TMPRSS4 gene on chromosome 11q23.3, this enzyme belongs to the type II transmembrane serine protease family (TTSPs) characterized by an N-terminal transmembrane domain, a stem region, and a C-terminal trypsin-like serine protease domain. TMPRSS4 is synthesized as a zymogen that undergoes autocatalytic activation to generate the mature active enzyme at the plasma membrane.\u003cbr\u003e\u003cbr\u003eTMPRSS4 is expressed in epithelial tissues of the gastrointestinal tract, lung, and kidney, as well as in certain tumors. It participates in the proteolytic activation of signaling molecules and extracellular matrix remodeling. Elevated TMPRSS4 expression has been linked to cancer invasion and metastasis through the activation of integrin and epithelial-mesenchymal transition pathways. TMPRSS4 promotes cell motility and survival by enhancing FAK and Src kinase signaling, modulating cytoskeletal organization, and upregulating matrix metalloproteinases.\u003cbr\u003e\u003cbr\u003eThe TMPRSS4 antibody is a critical reagent for cancer, developmental, and epithelial biology research. Western blot analysis typically identifies a 50-60 kilodalton band corresponding to the cleaved active form, while immunohistochemistry reveals membrane and cytoplasmic staining in epithelial cells and tumor tissues. The antibody allows detection of TMPRSS4 expression in normal and malignant tissues, aiding studies of protease-mediated signaling and tumor microenvironment remodeling.\u003cbr\u003e\u003cbr\u003eBeyond oncology, TMPRSS4 may regulate viral entry for certain coronaviruses and influenza strains by cleaving viral envelope glycoproteins. Its involvement in epithelial homeostasis and infection response makes it an emerging therapeutic target.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TMPRSS4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TMPRSS4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TMPRSS4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TMPRSS4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TMPRSS4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047298654573,"sku":"FY12742","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5ff16a4b-5ff4-41e4-9e1f-434773d4684a.jpg?v=1782237040","url":"https:\/\/www.ebiohippo.com\/products\/tmprss4-antibody-transmembrane-protease-serine-4-bha17135645","provider":"BioHippo","version":"1.0","type":"link"}