{"product_id":"tnf-r1-antibody-bha11906982","title":"TNF-R1 Antibody","description":"\u003cp\u003eTumor necrosis factor receptor 1 (TNF-R1), also known as CD120a or p55\/p60, is a high-affinity receptor for tumor necrosis factor-alpha (TNF-α) and a key member of the TNF\/TNFR superfamily. Structurally, TNF-R1 features an extracellular domain with multiple cysteine-rich repeats and a cytoplasmic death domain that initiates downstream signaling cascades.\u003c\/p\u003e\n\n\u003cp\u003eTNF-R1 is widely expressed in the central nervous system, including neurons, astrocytes, and microglia. Upon binding TNF-α, TNF-R1 activates multiple intracellular pathways, including NF-κB-mediated inflammation and caspase-dependent apoptosis. This dual functionality allows TNF-R1 to regulate both cell survival and programmed cell death, depending on the cellular context and signaling environment.\u003c\/p\u003e\n\n\u003cp\u003eIn neurodegenerative disease research, TNF-R1 has emerged as a critical mediator of chronic neuroinflammation and neuronal loss. Aberrant TNF-R1 signaling is implicated in the pathogenesis of Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). Sustained activation of TNF-R1 can exacerbate oxidative stress, synaptic dysfunction, and glial reactivity—hallmarks of progressive neurodegeneration.\u003c\/p\u003e\n\n\u003cp\u003eGiven its central role in immune signaling and apoptosis, TNF-R1 is a promising therapeutic target for modulating neuroinflammatory responses and protecting neuronal integrity in neurodegenerative disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040793223533,"sku":"SPC-170D","price":317.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040875012461,"sku":"SPC-170D-A390","price":372.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040875045229,"sku":"SPC-170D-A488","price":370.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040875077997,"sku":"SPC-170D-A594","price":370.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040875110765,"sku":"SPC-170D-APC","price":369.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040875143533,"sku":"SPC-170D-BI","price":366.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040875176301,"sku":"SPC-170D-FITC","price":361.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040875209069,"sku":"SPC-170D-HRP","price":357.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040875241837,"sku":"SPC-170D-PCP","price":369.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040875274605,"sku":"SPC-170D-RPE","price":367.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040875307373,"sku":"SPC-170S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-170_TNF-R1_Antibody_ICC-IF_Human_HeLa-Cells_100x_Composite.png?v=1771832156","url":"https:\/\/www.ebiohippo.com\/products\/tnf-r1-antibody-bha11906982","provider":"BioHippo","version":"1.0","type":"link"}