{"product_id":"tnfaip8-antibody-tumor-necrosis-factor-alpha-induced-protein-8-bha17135774","title":"TNFAIP8 Antibody \/ Tumor necrosis factor alpha induced protein 8","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTNFAIP8 Antibody \/ Tumor necrosis factor alpha induced protein 8 is a anti-TNFAIP8 Rabbit antibody Recombinant Rabbit Monoclonal clone 30T22 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TNFAIP8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30T22, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTNFAIP8 antibody detects Tumor necrosis factor alpha induced protein 8, encoded by the TNFAIP8 gene. This protein is part of the TNFAIP8 family, which includes several paralogs involved in apoptosis regulation, immune modulation, and cancer biology. TNFAIP8 has been described as an anti apoptotic factor that suppresses programmed cell death and influences cell survival pathways in response to cytokine signaling. Research using TNFAIP8 antibody has demonstrated that it contributes to immune evasion in tumors and enhances the survival of malignant cells under stress conditions, making it highly relevant in oncology studies.\u003cbr\u003e\u003cbr\u003eTNFAIP8 is induced by TNF signaling and is involved in modulating NF kappa B activity. Studies indicate that it can inhibit caspase activation and reduce apoptosis, thereby promoting cell survival under stress conditions. By altering apoptosis thresholds, TNFAIP8 helps cancer cells persist in hostile microenvironments where other cells would undergo death. Detection with TNFAIP8 antibody has shown elevated expression in multiple cancers, including lung, colon, and ovarian carcinoma, where it contributes to chemoresistance and poor prognosis. Its regulation of immune signaling pathways makes it a target of interest in both immunology and oncology, as it may serve as a biomarker for aggressiveness and therapeutic resistance.\u003cbr\u003e\u003cbr\u003eBeyond its role in apoptosis, TNFAIP8 may participate in vesicle trafficking and autophagy. It has been implicated in lipid binding and membrane dynamics, linking it to cellular stress responses and nutrient sensing. Evidence suggests that TNFAIP8 can modulate PI3K AKT signaling, further highlighting its role in integrating survival and metabolic pathways. Researchers employing TNFAIP8 antibody can explore these broader functions and their relevance in pathological conditions, including inflammatory diseases where dysregulated cell survival exacerbates tissue injury.\u003cbr\u003e\u003cbr\u003eTNFAIP8 antibody is commonly used in western blotting, immunohistochemistry, and ELISA. Western blotting identifies isoform expression and quantitative changes, while immunohistochemistry reveals expression patterns in tumor samples and immune tissues, offering insights into microenvironmental interactions. ELISA based assays extend applications to serum measurements in clinical samples, where circulating TNFAIP8 may serve as a biomarker for disease severity. Flow cytometry applications have also been developed, enabling detection in heterogeneous cell populations.\u003cbr\u003e\u003cbr\u003eResearch into tumor biology, inflammation, and therapeutic resistance benefits from reliable antibodies such as TNFAIP8 antibody. By providing validated reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TNFAIP8 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TNFAIP8 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TNFAIP8 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TNFAIP8 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TNFAIP8+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047304520045,"sku":"FY12872","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d7d9e2fb-77e8-4183-b135-b98d3dc638dd.jpg?v=1772019354","url":"https:\/\/www.ebiohippo.com\/products\/tnfaip8-antibody-tumor-necrosis-factor-alpha-induced-protein-8-bha17135774","provider":"BioHippo","version":"1.0","type":"link"}