{"product_id":"tnfrsf10d-antibody-trail-r4-tumor-necrosis-factor-receptor-superfamily-member-10d-bha17135239","title":"TNFRSF10D Antibody \/ TRAIL-R4 \/ Tumor necrosis factor receptor superfamily member 10D","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTNFRSF10D Antibody \/ TRAIL-R4 \/ Tumor necrosis factor receptor superfamily member 10D is a anti-TNFRSF10D Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse. Reported localization: Plasma membrane, Actin filaments.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TNFRSF10D\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe TNFRSF10D antibody targets tumor necrosis factor receptor superfamily member 10D, also known as decoy receptor 2 or TRAIL receptor 4. TNFRSF10D is a type I transmembrane receptor that belongs to the broader TNF receptor superfamily, which mediates responses to cytokines such as TNF and related ligands. Unlike other death receptors in the TRAIL receptor family, TNFRSF10D lacks a functional cytoplasmic death domain. This structural difference prevents the receptor from transmitting apoptotic signals upon TRAIL binding, effectively classifying TNFRSF10D as a decoy receptor. By competing for TRAIL without inducing apoptosis, TNFRSF10D serves as a protective modulator, regulating the balance between cell death and survival in tissues exposed to TRAIL signaling.\u003cbr\u003e\u003cbr\u003eTNFRSF10D is encoded by the TNFRSF10D gene on chromosome 8p21 and is expressed in a wide range of tissues, including immune system cells, epithelial tissues, and endothelial cells. Its ability to act as a natural antagonist to apoptosis induction has made it a focus of cancer research. In tumors, TNFRSF10D expression may influence sensitivity to TRAIL-based therapies by preventing cell death, thereby contributing to resistance. The TNFRSF10D antibody provides a means to examine receptor expression across tumor models and to assess its regulatory role in survival pathways. Beyond oncology, the receptor may also play roles in immune homeostasis and tissue protection under stress conditions.\u003cbr\u003e\u003cbr\u003eThe TNFRSF10D antibody can be applied to a variety of experimental platforms. Western blotting provides insights into receptor expression and post-translational modifications. Immunohistochemistry enables the detection of TNFRSF10D across different tissue sections, offering information about its spatial distribution. Flow cytometry can quantify receptor levels on the surface of immune cell subsets, clarifying its function in regulating TRAIL-mediated apoptosis. These experimental approaches make the TNFRSF10D antibody a versatile research tool for investigating receptor biology.\u003cbr\u003e\u003cbr\u003eInterest in TRAIL receptor biology continues to expand as researchers explore therapeutic strategies to induce apoptosis in cancer cells. Since TNFRSF10D counteracts the apoptotic effect of TRAIL, it has been proposed as a therapeutic target for sensitizing resistant cells. The availability of the TNFRSF10D antibody through\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TNFRSF10D - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TNFRSF10D - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TNFRSF10D - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TNFRSF10D - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TNFRSF10D+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047285612909,"sku":"FY12336","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e0f21ae3-eb9a-4688-84e6-7a0f3ecaf0f8.jpg?v=1782236999","url":"https:\/\/www.ebiohippo.com\/products\/tnfrsf10d-antibody-trail-r4-tumor-necrosis-factor-receptor-superfamily-member-10d-bha17135239","provider":"BioHippo","version":"1.0","type":"link"}