{"product_id":"tnfrsf19-antibody-tumor-necrosis-factor-receptor-superfamily-member-19-bha17135879","title":"TNFRSF19 Antibody \/ Tumor necrosis factor receptor superfamily member 19","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTNFRSF19 Antibody \/ Tumor necrosis factor receptor superfamily member 19 is a anti-TNFRSF19 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TNFRSF19\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTNFRSF19 antibody detects Tumor necrosis factor receptor superfamily member 19, a transmembrane receptor that mediates signaling involved in development, apoptosis, and immune regulation. The UniProt recommended name is Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY. This receptor is a member of the TNF receptor family, sharing structural similarity with other death-domain-containing receptors but functioning in both survival and differentiation signaling contexts.\u003cbr\u003e\u003cbr\u003eFunctionally, TNFRSF19 antibody identifies a 417-amino-acid receptor that participates in multiple signaling pathways including NF-kappaB, JNK, and MAPK cascades. TNFRSF19 binds members of the TNF ligand family and modulates downstream transcriptional programs controlling apoptosis, cell fate determination, and inflammation. In the nervous system, TNFRSF19 plays a crucial role in axon guidance, myelination, and neuronal survival. It is expressed in developing neural tissues, keratinocytes, and various epithelial cells.\u003cbr\u003e\u003cbr\u003eThe TNFRSF19 gene is located on chromosome 13q12.11 and encodes a single-pass type I membrane protein with an extracellular cysteine-rich domain, a transmembrane segment, and an intracellular death domain-like region. This structure allows TNFRSF19 to act as both a receptor and signaling adaptor. It interacts with TRAF2 and TRADD adaptor proteins to regulate NF-kappaB activation and cell survival. In developmental processes, TNFRSF19 coordinates Wnt and BMP signaling, influencing neural crest differentiation and epidermal homeostasis.\u003cbr\u003e\u003cbr\u003eIn cancer biology, TNFRSF19 exhibits dual roles depending on cellular context. Its overexpression has been linked to glioma and pancreatic cancer progression through activation of pro-survival pathways, while in other cancers, its expression suppresses metastasis by promoting apoptosis. TNFRSF19 also participates in immune regulation, influencing macrophage activation and inflammatory cytokine production.\u003cbr\u003e\u003cbr\u003eTNFRSF19 antibody is widely used in studies of apoptosis, neurobiology, and immune signaling. It is suitable for immunoblotting, immunohistochemistry, and flow cytometry to detect receptor localization and expression levels. In developmental biology, TNFRSF19 serves as a marker for neural crest derivatives and epithelial differentiation. Its detection provides insight into the balance between cell survival and programmed death in both normal and disease contexts.\u003cbr\u003e\u003cbr\u003eStructurally, TNFRSF19 shares conserved cysteine-rich motifs with other TNF receptor family members that mediate ligand binding and receptor trimerization. Its cytoplasmic domain associates with adaptor proteins to propagate intracellular signaling.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TNFRSF19 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TNFRSF19 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TNFRSF19 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TNFRSF19 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TNFRSF19+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047307501933,"sku":"FY12977","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_356c0eb6-398e-4369-ab94-c8212744a125.jpg?v=1782237072","url":"https:\/\/www.ebiohippo.com\/products\/tnfrsf19-antibody-tumor-necrosis-factor-receptor-superfamily-member-19-bha17135879","provider":"BioHippo","version":"1.0","type":"link"}