{"product_id":"tnip3-antibody-tnfaip3-interacting-protein-3-bha17136048","title":"TNIP3 Antibody \/ TNFAIP3-interacting protein 3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTNIP3 Antibody \/ TNFAIP3-interacting protein 3 is a anti-TNIP3 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TNIP3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTNIP3 antibody detects TNFAIP3-interacting protein 3, an inhibitory regulator of NF-kappaB signaling that modulates inflammation and immune homeostasis. The UniProt recommended name is TNFAIP3-interacting protein 3 (TNIP3). This cytoplasmic protein binds the ubiquitin-editing enzyme A20 (TNFAIP3) to suppress NF-kappaB activation and prevent excessive inflammatory responses.\u003cbr\u003e\u003cbr\u003eFunctionally, TNIP3 antibody identifies a 619-amino-acid adaptor protein that interacts with polyubiquitinated signaling intermediates in TNF and Toll-like receptor pathways. TNIP3 limits downstream signaling by promoting deubiquitination and degradation of key components such as TRAF6 and RIPK1. Through its regulatory activity, TNIP3 maintains immune balance and protects against chronic inflammation.\u003cbr\u003e\u003cbr\u003eThe TNIP3 gene is located on chromosome 4p15.2 and is expressed in immune tissues including spleen, lymph nodes, and macrophages. It is inducible by proinflammatory cytokines and interferons, functioning as part of a negative feedback loop to terminate NF-kappaB signaling. TNIP3 also contributes to cellular responses to oxidative stress and apoptosis.\u003cbr\u003e\u003cbr\u003ePathologically, dysregulation of TNIP3 has been linked to autoimmune and inflammatory diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Altered TNIP3 expression may enhance susceptibility to chronic immune activation. Research using TNIP3 antibody supports studies in inflammation, signal transduction, and immune regulation.\u003cbr\u003e\u003cbr\u003eTNIP3 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect NF-kappaB regulatory proteins. \u003cbr\u003e\u003cbr\u003eStructurally, TNFAIP3-interacting protein 3 contains multiple ubiquitin-binding domains that recognize polyubiquitin chains and mediate interaction with A20. This antibody facilitates investigation of TNIP3's function in inflammatory signaling and immune tolerance.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TNIP3 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TNIP3 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TNIP3 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TNIP3 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TNIP3+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047313465709,"sku":"FY13146","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4b08dec3-e2ea-44dd-94a3-f3e15c4448d2.jpg?v=1782237096","url":"https:\/\/www.ebiohippo.com\/products\/tnip3-antibody-tnfaip3-interacting-protein-3-bha17136048","provider":"BioHippo","version":"1.0","type":"link"}