{"product_id":"tns4-antibody-tensin-4-cten-bha17135722","title":"TNS4 Antibody \/ Tensin 4 \/ Cten","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTNS4 Antibody \/ Tensin 4 \/ Cten is a anti-TNS4 Rabbit antibody Recombinant Rabbit Monoclonal clone 30T19 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TNS4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30T19, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTNS4 antibody detects tensin 4, encoded by the TNS4 gene. This protein is also known as Cten, cancer associated tensin, and tensin like C1 domain containing phosphatase 1 related protein. TNS4 belongs to the tensin family of focal adhesion proteins that link actin cytoskeleton to integrins and signaling molecules. Unlike other tensins, TNS4 lacks the phosphatase domain but retains SH2 and PTB domains that mediate signaling interactions. TNS4 localizes to focal adhesions and regulates adhesion, migration, and invasion. Its expression is low in normal tissues but highly upregulated in many cancers.\u003cbr\u003e\u003cbr\u003eTNS4 antibody is widely applied in cancer biology, cell adhesion studies, and migration research. TNS4 expression is elevated in colorectal, gastric, breast, and lung cancers, where it promotes epithelial mesenchymal transition, invasion, and metastasis. By detecting TNS4, researchers can evaluate how altered focal adhesion dynamics contribute to tumor progression. Its restricted expression in normal tissues and strong induction in tumors make it a promising biomarker for oncogenesis.\u003cbr\u003e\u003cbr\u003eApplications of TNS4 antibody include western blotting, immunohistochemistry, and immunofluorescence. Western blot assays detect TNS4 protein in tumor cell lysates, immunohistochemistry maps expression in cancer biopsies, and immunofluorescence highlights localization at adhesion sites. These methods provide robust experimental approaches for studying cancer associated focal adhesion remodeling.\u003cbr\u003e\u003cbr\u003eTNS4 interacts with integrins, focal adhesion kinase, and actin filaments, coordinating adhesion and signaling. Unlike other tensins, its lack of phosphatase activity suggests specialized roles in signaling rather than enzymatic regulation. By applying TNS4 antibody, scientists can dissect how this atypical tensin supports oncogenic processes. TNS4 expression correlates with poor prognosis, therapy resistance, and metastatic potential in multiple cancers.\u003cbr\u003e\u003cbr\u003eBeyond cancer, TNS4 has roles in wound healing and tissue repair, where transient expression supports migration and remodeling. Its evolutionary divergence from other tensins highlights specialized functions. Detection with antibody based assays enables researchers to map these unique contributions across physiology and pathology.\u003cbr\u003e\u003cbr\u003eTNS4 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TNS4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TNS4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TNS4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TNS4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TNS4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047303111021,"sku":"FY12820","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_76ab49eb-78c6-49f0-bb68-51c093b61cd0.jpg?v=1772019349","url":"https:\/\/www.ebiohippo.com\/products\/tns4-antibody-tensin-4-cten-bha17135722","provider":"BioHippo","version":"1.0","type":"link"}