{"product_id":"tor4a-antibody-torsin-family-4-member-a-bha17136289","title":"TOR4A Antibody \/ Torsin family 4 member A","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTOR4A Antibody \/ Torsin family 4 member A is a anti-TOR4A Rabbit antibody Recombinant Rabbit Monoclonal clone 29T65 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TOR4A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29T65, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTOR4A antibody detects Torsin family 4 member A, encoded by the TOR4A gene. Torsin family 4 member A is a member of the AAA+ ATPase family of proteins, localized to the endoplasmic reticulum and nuclear envelope. TOR4A antibody provides researchers with a useful reagent to study endoplasmic reticulum biology, protein homeostasis, and nuclear envelope function.\u003cbr\u003e\u003cbr\u003eTorsin family 4 member A is part of a family of ATPases that contribute to protein folding, trafficking, and quality control. Research using TOR4A antibody has shown that the protein supports structural organization of the endoplasmic reticulum and nuclear envelope. By interacting with other torsin proteins, TOR4A participates in maintaining organelle integrity and proteostasis under basal and stress conditions.\u003cbr\u003e\u003cbr\u003eStudies with TOR4A antibody have revealed that the protein is involved in nuclear envelope structure and potentially nuclear pore dynamics. Disruption of torsin family proteins has been linked to nuclear envelope abnormalities and impaired nucleocytoplasmic transport. These findings suggest that TOR4A contributes to essential processes that support gene regulation and cell signaling.\u003cbr\u003e\u003cbr\u003eDysregulation of TOR4A has been implicated in disease. Research using TOR4A antibody has shown associations with cancer progression and viral infection. Overexpression in certain cancers correlates with altered protein folding capacity and stress adaptation, while some pathogens exploit torsin family proteins for replication. These findings underscore the relevance of TOR4A in health and pathology.\u003cbr\u003e\u003cbr\u003eTOR4A antibody is commonly applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects endogenous protein levels, immunohistochemistry reveals tissue-specific expression, and immunofluorescence demonstrates localization to the endoplasmic reticulum and nuclear envelope. These applications make TOR4A antibody valuable for cell biology research.\u003cbr\u003e\u003cbr\u003eBy providing validated TOR4A antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TOR4A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TOR4A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TOR4A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TOR4A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TOR4A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047324311917,"sku":"FY13387","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_77c43188-517b-4cfe-b120-60eb273cc3fd.jpg?v=1772019439","url":"https:\/\/www.ebiohippo.com\/products\/tor4a-antibody-torsin-family-4-member-a-bha17136289","provider":"BioHippo","version":"1.0","type":"link"}