{"product_id":"trail-r4-antibody-tnfrsf10d-trundd-bha17136364","title":"TRAIL-R4 Antibody \/ TNFRSF10D \/ TRUNDD","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTRAIL-R4 Antibody \/ TNFRSF10D \/ TRUNDD is a anti-TRAIL-R4 Rabbit antibody Recombinant Rabbit Monoclonal clone 23T76 supplied in Purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Human, Mouse. Reported localization: Plasma membrane, Actin filaments.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRAIL-R4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 23T76, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTRAIL R4 antibody is a useful reagent for investigating apoptosis, immune regulation, and cancer biology. The encoded protein, TNFRSF10D (also known as TRUNDD or TRAIL receptor 4), is a member of the tumor necrosis factor receptor superfamily. Unlike TRAIL receptors that signal apoptosis, TRAIL R4 lacks a functional death domain and instead acts as a decoy receptor for TRAIL (TNF related apoptosis inducing ligand). By binding TRAIL without transmitting apoptotic signals, TNFRSF10D protects cells from TRAIL mediated cell death and modulates sensitivity to immune surveillance.\u003cbr\u003e\u003cbr\u003eTRAIL R4 is expressed in a variety of tissues and cell types, including immune cells and epithelial cells. Its expression pattern suggests a role in maintaining tissue homeostasis by preventing inappropriate activation of apoptosis. In addition, TRAIL R4 has been shown to activate pro survival pathways such as NF kappa B and PI3K Akt signaling, further supporting its function as a regulator of cell fate. These properties distinguish it from TRAIL receptors DR4 and DR5, which contain functional death domains and induce apoptosis.\u003cbr\u003e\u003cbr\u003eResearch has linked TNFRSF10D to tumor biology. Overexpression of TRAIL R4 in cancer cells provides resistance to TRAIL mediated killing, allowing malignant cells to evade immune destruction. This mechanism contributes to tumor progression and therapeutic resistance in cancers such as colon, breast, and lung carcinoma. Because of this protective effect, TRAIL R4 is studied as both a biomarker and a potential target for overcoming resistance in TRAIL based therapies. Its role in modulating survival pathways also makes it relevant in studies of inflammation and immune regulation.\u003cbr\u003e\u003cbr\u003eAt the molecular level, TRAIL R4 contains extracellular cysteine rich domains typical of TNF receptors but a truncated intracellular domain that lacks apoptotic signaling capacity. This structure enables it to compete with death inducing TRAIL receptors for ligand binding, thereby controlling the balance between apoptosis and survival. Functional studies indicate that TRAIL R4 can redirect TRAIL signaling toward non apoptotic outcomes, influencing proliferation and inflammatory responses.\u003cbr\u003e\u003cbr\u003eThe TRAIL R4 antibody is widely used in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to measure protein expression and localization. These applications are critical for cancer research, apoptosis studies, and immune regulation. For scientists exploring tumor immune evasion, cytokine receptor signaling, or therapeutic interventions, the TRAIL R4 antibody provides a reliable detection tool.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TRAIL-R4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TRAIL-R4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TRAIL-R4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TRAIL-R4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TRAIL-R4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047327424877,"sku":"RQ8946","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f9c2ea27-9432-4f04-852c-cabddb457fc7.jpg?v=1772019450","url":"https:\/\/www.ebiohippo.com\/products\/trail-r4-antibody-tnfrsf10d-trundd-bha17136364","provider":"BioHippo","version":"1.0","type":"link"}