{"product_id":"trim11-antibody-tripartite-motif-containing-protein-11-bha17135363","title":"TRIM11 Antibody \/ Tripartite motif-containing protein 11","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTRIM11 Antibody \/ Tripartite motif-containing protein 11 is a anti-TRIM11 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRIM11\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTRIM11 antibody recognizes Tripartite motif-containing protein 11, an E3 ubiquitin-protein ligase that plays a central role in protein quality control, neuronal regulation, and innate immunity. TRIM11 belongs to the TRIM family of proteins, which share a conserved architecture comprising a RING finger domain, one or two B-box motifs, and a coiled-coil region. This configuration enables TRIM11 to act as a multifunctional scaffold for substrate recognition and ubiquitin transfer. The TRIM11 antibody is extensively used in molecular and cellular biology research to study ubiquitination, neurodegeneration, and cancer signaling networks that depend on proteostasis and regulated protein degradation.\u003cbr\u003e\u003cbr\u003eEncoded by the TRIM11 gene located on human chromosome 1q42.13, the protein is composed of approximately 465 amino acids and localizes predominantly to the cytoplasm, although nuclear accumulation occurs under specific stress conditions. Functionally, TRIM11 mediates the ubiquitination and degradation of misfolded or aggregated proteins, thereby maintaining neuronal homeostasis. It directly interacts with substrates such as Humanin, a neuroprotective peptide, and acts as a negative regulator of stress-induced signaling. Through its ubiquitin ligase activity, TRIM11 contributes to proteasome-mediated clearance of abnormal proteins, preventing cytotoxic accumulation observed in neurodegenerative diseases like Alzheimer's and Parkinson's.\u003cbr\u003e\u003cbr\u003eThe TRIM11 antibody is also valuable for studying tumorigenesis, as elevated TRIM11 expression has been reported in glioma, breast, and colorectal cancers. It promotes cell proliferation and migration by targeting tumor suppressors for degradation and by activating signaling pathways such as PI3K\/AKT and ERK\/MAPK. Additionally, TRIM11 can suppress interferon-stimulated gene expression, indicating a regulatory role in antiviral immunity. Western blot analyses using this antibody typically reveal a band near 52-55 kDa, corresponding to the full-length protein. Immunofluorescence assays show diffuse cytoplasmic localization with punctate distribution, consistent with its role in protein turnover and ubiquitin signaling.\u003cbr\u003e\u003cbr\u003eAt the molecular level, TRIM11 associates with proteasomal subunits and chaperone complexes, enhancing clearance of misfolded proteins generated during oxidative stress or viral infection. Knockdown studies reveal increased accumulation of aggregation-prone proteins and elevated sensitivity to stress-induced apoptosis, demonstrating TRIM11's role as a cellular quality control factor. The protein also regulates transcriptional activity by modulating the degradation of transcriptional co-repressors and signaling intermediates.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TRIM11 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TRIM11 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TRIM11 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TRIM11 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TRIM11+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047288660333,"sku":"FY12460","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_56405821-b4d7-4a0c-a012-38a66ed79c48.jpg?v=1782236994","url":"https:\/\/www.ebiohippo.com\/products\/trim11-antibody-tripartite-motif-containing-protein-11-bha17135363","provider":"BioHippo","version":"1.0","type":"link"}