{"product_id":"trim2-antibody-tripartite-motif-containing-protein-2-bha17135558","title":"TRIM2 Antibody \/ Tripartite motif-containing protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTRIM2 Antibody \/ Tripartite motif-containing protein 2 is a anti-TRIM2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, Mitochondria, ER.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRIM2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTRIM2 antibody detects Tripartite motif-containing protein 2, an E3 ubiquitin ligase that regulates neuronal cytoskeleton organization and axonal stability. TRIM2 belongs to the TRIM family of RING finger E3 ligases and mediates ubiquitination of neurofilament proteins and signaling regulators. The TRIM2 antibody is widely used in neuroscience, developmental, and cell biology research to study axon maintenance, neurodegeneration, and ubiquitin-mediated proteostasis.\u003cbr\u003e\u003cbr\u003eTRIM2 is encoded by the TRIM2 gene located on human chromosome 4q31.3. The protein is approximately 744 amino acids long and contains a RING finger domain, two B-boxes, a coiled-coil region, and a C-terminal filamin-binding NHL repeat domain. TRIM2 localizes to axons, growth cones, and perinuclear regions, reflecting its role in neuronal trafficking and cytoskeletal regulation.\u003cbr\u003e\u003cbr\u003eThe TRIM2 antibody detects a 90 kilodalton band by western blot and reveals filamentous cytoplasmic staining under immunofluorescence microscopy. TRIM2 ubiquitinates neurofilament light chain (NEFL) to control filament organization and turnover, maintaining axonal integrity and preventing neurodegenerative aggregation. It also regulates apoptosis by targeting proapoptotic proteins for degradation and interacts with signaling pathways involved in neuronal survival.\u003cbr\u003e\u003cbr\u003eMutations in TRIM2 cause hereditary axonal neuropathy and neurodegenerative disease characterized by axon swelling and degeneration. Dysregulation of TRIM2 expression has also been linked to gliomas and other cancers, where altered ubiquitination affects cytoskeletal dynamics and invasion. In developing neurons, TRIM2 coordinates cytoskeletal remodeling during axon guidance and branching.\u003cbr\u003e\u003cbr\u003eBecause of its key role in ubiquitin-mediated regulation of the neuronal cytoskeleton, TRIM2 serves as an essential molecule for understanding axonal maintenance and neuroprotection.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TRIM2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TRIM2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TRIM2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TRIM2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TRIM2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047295705453,"sku":"FY12655","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_bfa469d0-8b2b-4f44-95eb-c6c6f639f830.jpg?v=1782237030","url":"https:\/\/www.ebiohippo.com\/products\/trim2-antibody-tripartite-motif-containing-protein-2-bha17135558","provider":"BioHippo","version":"1.0","type":"link"}